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PDGFRB and PTPRJ
Number of citations of the paper that reports this interaction (PubMedID
12062403
)
0
Data Source:
HPRD
(in vitro, in vivo)
PDGFRB
PTPRJ
Description
platelet derived growth factor receptor beta
protein tyrosine phosphatase receptor type J
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Immunological Synapse
Extracellular Region
Nucleoplasm
Nucleolus
Plasma Membrane
Cell-cell Junction
Cell Surface
Membrane
Nuclear Body
Cell Junction
Ruffle Membrane
Specific Granule Membrane
Cell Projection
Extracellular Exosome
Anchoring Junction
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Beta-catenin Binding
Hydrolase Activity
Phosphatase Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Mitogen-activated Protein Kinase Binding
Delta-catenin Binding
Biological Process
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Angiogenesis
Vasculogenesis
Positive Regulation Of Cell-matrix Adhesion
Immune System Process
Signal Transduction
Axon Guidance
Heart Development
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Positive Regulation Of Platelet Activation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Macrophage Chemotaxis
Cytokine-mediated Signaling Pathway
Hemopoiesis
Regulation Of Cell Adhesion
B Cell Differentiation
Platelet Formation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Tumor Necrosis Factor Production
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Glucose Homeostasis
Negative Regulation Of Vascular Permeability
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Negative Regulation Of Insulin Receptor Signaling Pathway
Platelet-derived Growth Factor Receptor Signaling Pathway
Oligodendrocyte Differentiation
Positive Regulation Of Phagocytosis
Positive Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Contact Inhibition
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Biological Quality
Positive Regulation Of Intracellular Signal Transduction
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity
Negative regulation of FLT3
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Acute lymphoblastic leukemia (childhood) (
22076464
)
Alanine aminotransferase levels (
33547301
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Aspartate aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Caffeine consumption from coffee or tea (
33287642
)
D-dimer levels (
21502573
)
Experiencing mood swings (
29500382
)
Heel bone mineral density (
30598549
)
Height (
28552196
25282103
23563607
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hypertension (
31879980
)
Intraocular pressure (
31798171
31959993
30054594
29785010
29617998
29235454
25173106
)
Kawasaki disease (
33692975
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Serum alkaline phosphatase levels (
33547301
)
Serum metabolite concentrations in chronic kidney disease (
33838163
)
Sleep duration (short sleep) (
30846698
)
Interacting Genes
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
37 interacting genes:
ANP32B
BAAT
BAP1
CASC3
CNKSR1
CTNNB1
CTNND1
CYP17A1
EGFR
EPSTI1
FANCC
FBP1
HEMGN
HOXC6
HRAS
IL2RG
JUP
KLK7
KLK9
LAT
LYPD3
MAP2K1
MET
NANS
NOP2
PDGFRB
PLCG1
PPP2CB
PPP3R2
PRDM14
RASA1
SDCBP
SFRP4
TMEFF1
TRMO
TSTD2
ZNF510
Entrez ID
5159
5795
HPRD ID
01423
02955
Ensembl ID
ENSG00000113721
ENSG00000149177
Uniprot IDs
P09619
Q59F04
Q12913
Q9NPR5
PDB IDs
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
2CFV
2DLE
2NZ6
7U01
7U08
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Catenin-TCF7L2 Complex
Phospholipase C Activator Activity
ERBB Signaling Pathway
Cellular Response To Indole-3-methanol
Positive Regulation Of MAPK Cascade
Catenin Complex
Cell Morphogenesis
Protein Phosphatase Binding
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Locomotion
Positive Regulation Of Cell Motility
Regulation Of Signal Transduction
Response To Indole-3-methanol
Cell-cell Junction
Trachea Formation
Regulation Of Blood Vessel Branching
Regulation Of Calcium Ion Import
Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
Protein Tyrosine Kinase Activity
Alpha-catenin Binding
Phosphatase Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphorylation
Vasculature Development
Regulation Of Cell Motility
Focal Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Transport
Regulation Of Signaling
Regulation Of Locomotion
Negative Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Transport
Intracellular Signaling Cassette
Tube Morphogenesis
Regulation Of MAPK Cascade
Histone Methyltransferase Binding
Regulation Of Cell Population Proliferation
Ciliary Basal Body
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Phosphate Metabolic Process
Regulation Of Protein Localization
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Ras Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Adherens Junction
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Tagcloud (Difference)
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Tagcloud (Intersection)
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