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PDGFRB and JAK2
Number of citations of the paper that reports this interaction (PubMedID
8657151
)
54
Data Source:
HPRD
(in vitro, in vivo)
PDGFRB
JAK2
Description
platelet derived growth factor receptor beta
Janus kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Caveola
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Endosome Lumen
Interleukin-12 Receptor Complex
Membrane Raft
Interleukin-23 Receptor Complex
Postsynapse
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Growth Hormone Receptor Binding
Interleukin-12 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heme Binding
Signaling Receptor Activator Activity
Type 1 Angiotensin Receptor Binding
Acetylcholine Receptor Binding
Histone H3Y41 Kinase Activity
SH2 Domain Binding
Histone Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Peptide Hormone Receptor Binding
Biological Process
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Apoptotic Process
Immune Response
Response To Oxidative Stress
Cell Adhesion
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Hormone-mediated Signaling Pathway
Positive Regulation Of Platelet Activation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cell-substrate Adhesion
Cytokine-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell-cell Adhesion
Actin Filament Polymerization
Myeloid Cell Differentiation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Axon Regeneration
Lipopolysaccharide-mediated Signaling Pathway
Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Proliferation
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Symbiont-induced Defense-related Programmed Cell Death
Response To Tumor Necrosis Factor
Post-embryonic Hemopoiesis
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Cellular Response To Interleukin-3
Interleukin-5-mediated Signaling Pathway
Collagen-activated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Post-translational Protein Modification
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Response To Antibiotic
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Inflammatory Response
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cell Activation
Positive Regulation Of NK T Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Type II Interferon-mediated Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Epithelium Development
Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Leukocyte Proliferation
Response To Interleukin-12
Interleukin-35-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Dexamethasone Stimulus
Extrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cold-induced Thermogenesis
Defense Response To Symbiont
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Signaling by Erythropoietin
Signaling by Erythropoietin
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
IFNG signaling activates MAPKs
Growth hormone receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
XL019
5-phenyl-1H-indazol-3-amine
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
Ruxolitinib
Tofacitinib
Pacritinib
Baricitinib
Entrectinib
Fostamatinib
Fedratinib
Abrocitinib
Zanubrutinib
Pralsetinib
Diseases
Glioma
Polycythemia vera
GWAS
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
23266558
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Eosinophilic esophagitis (
34506852
)
HDL cholesterol (
30275531
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol (
30275531
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
19287384
25849990
33057200
)
Neutrophil count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
24777453
32888494
27863252
28031487
)
Plateletcrit (
27863252
32888494
)
Psoriatic arthritis (
26626624
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
19915573
20228799
21297633
26398853
)
White blood cell count (
32888494
)
Interacting Genes
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
99 interacting genes:
ABL1
AGTR1
ARL11
ASS1
BCR
BRCA1
CBL
CCR5
CISH
CRLF2
CSF2RB
CSF3R
CTLA4
CXCR4
DNAJA3
EGFR
ELP2
EPOR
ERBB2
ERBB3
EZH2
FES
FYN
GHR
GRB10
GRB2
GTF2I
H3-4
HES1
HES5
HSFY1
HSPA8
HTR2A
IFNGR1
IFNGR2
IGF1R
IKBKG
IL12RB2
IL23R
IL3RA
IL4R
IL5RA
INSR
IRS1
IRS2
JAK1
JAK3
KIT
LEPR
LYN
MAP3K5
MDK
MPL
MST1R
NFKBIA
OSMR
PDGFRB
PIK3R1
PKD1
PLCG2
PPIA
PPP1CC
PPP2CA
PPP2R1B
PPP2R5A
PRLR
PRMT5
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN6
PTPRC
RAF1
RBMX
SH2B1
SH2B2
SHC1
SIRPA
SOCS1
SOCS3
STAM
STAM2
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
TEC
TNFRSF1A
TRAF6
TSHR
TUB
UBASH3B
VAV1
VCP
YES1
Entrez ID
5159
3717
HPRD ID
01423
00993
Ensembl ID
ENSG00000113721
ENSG00000096968
Uniprot IDs
P09619
Q59F04
A8K910
B4DYV1
O60674
PDB IDs
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
2B7A
2W1I
2XA4
3E62
3E63
3E64
3FUP
3IO7
3IOK
3JY9
3KCK
3KRR
3LPB
3Q32
3RVG
3TJC
3TJD
3UGC
3ZMM
4AQC
4BBE
4BBF
4C61
4C62
4D0W
4D0X
4D1S
4E4M
4E6D
4E6Q
4F08
4F09
4FVP
4FVQ
4FVR
4GFM
4GMY
4HGE
4IVA
4JI9
4JIA
4P7E
4YTC
4YTF
4YTH
4YTI
4Z32
4ZIM
5AEP
5CF4
5CF5
5CF6
5CF8
5HEZ
5I4N
5L3A
5TQ3
5TQ4
5TQ5
5TQ6
5TQ7
5TQ8
5USY
5USZ
5UT0
5UT1
5UT2
5UT3
5UT4
5UT5
5UT6
5WEV
5WIJ
5WIK
5WIL
5WIM
5WIN
6AAJ
6BBV
6BRW
6BS0
6BSS
6D2I
6DRW
6E2P
6E2Q
6G3C
6M9H
6OAV
6OBB
6OBF
6OBL
6OCC
6TPD
6VGL
6VN8
6VNB
6VNC
6VNE
6VNF
6VNG
6VNH
6VNI
6VNJ
6VNK
6VNL
6VNM
6VS3
6VSN
6WTN
6WTO
6WTP
6WTQ
6X8E
6XJK
7F7W
7JYO
7JYQ
7LL4
7LL5
7Q7I
7Q7K
7Q7L
7Q7W
7REE
7RN6
7SZW
7T0P
7T1T
7TEU
7UYW
8B8N
8B8U
8B99
8B9E
8B9H
8BA2
8BA3
8BA4
8BAB
8BAK
8BM2
8BPV
8BPW
8BX6
8BX9
8BXC
8BXH
8C08
8C09
8C0A
8CZ9
8EX0
8EX1
8EX2
8EXK
8EYA
8EYB
8F88
8G6Z
8G8O
8G8X
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine Receptor Activity
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway Via STAT
Receptor Complex
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Protein Tyrosine Kinase Activity
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Cytokine Binding
Regulation Of Cell Differentiation
Regulation Of Developmental Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell-cell Adhesion
Positive Regulation Of Metabolic Process
Positive Regulation Of Immune System Process
Regulation Of Cell Activation
Cell Activation
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Regulation Of Cell Development
Positive Regulation Of Lymphocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Phosphotyrosine Residue Binding
Positive Regulation Of Cell Activation
Growth Hormone Receptor Signaling Pathway
Leukocyte Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Hemopoiesis
Regulation Of MAPK Cascade
Regulation Of Programmed Cell Death
Response To Cytokine
Regulation Of T Cell Activation
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Tagcloud (Intersection)
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