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PDGFRB and PDGFRA
Number of citations of the paper that reports this interaction (PubMedID
35384245
)
105
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
PDGFRB
PDGFRA
Description
platelet derived growth factor receptor beta
platelet derived growth factor receptor alpha
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
Cilium
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Cell Junction
Protein-containing Complex
Cell Projection
Receptor Complex
Platelet-derived Growth Factor Receptor-ligand Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Biological Process
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Luteinization
In Utero Embryonic Development
Cell Activation
Hematopoietic Progenitor Cell Differentiation
Chemotaxis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Estrogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Female Gonad Development
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Negative Regulation Of Platelet Activation
Cell Migration
Peptidyl-tyrosine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Extracellular Matrix Organization
Lung Development
Adrenal Gland Development
Positive Regulation Of Cell Migration
Male Genitalia Development
Regulation Of Actin Cytoskeleton Organization
Leydig Cell Differentiation
Cellular Response To Reactive Oxygen Species
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Odontogenesis Of Dentin-containing Tooth
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Skeletal System Morphogenesis
Positive Regulation Of Calcium-mediated Signaling
White Fat Cell Differentiation
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Roof Of Mouth Development
Face Morphogenesis
Cell Chemotaxis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Amino Acid Stimulus
Metanephric Glomerular Capillary Formation
Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Becaplermin
Imatinib
Sunitinib
XL820
Olaratumab
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin keratinocyte (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Ripretinib
Diseases
Glioma
Glioma
GWAS
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Adult asthma (
27611488
)
Asthma (
27611488
)
Blood protein levels (
30072576
)
Cadmium levels (
26025379
)
Core binding factor acute myeloid leukemia (
27903959
)
Corneal astigmatism (
29422769
22144915
)
Corneal curvature (
24963161
23401653
21665993
)
Height (
18193045
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Macular thickness (
30535121
)
Mean corpuscular hemoglobin (
20139978
29403010
)
Mean corpuscular volume (
29403010
20139978
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
30578418
)
Red blood cell count (
28453575
29403010
20139978
)
Serum VEGFR2 concentration (
25411163
)
Systolic blood pressure (
30578418
)
Uterine fibroids (
30194396
31649266
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
62 interacting genes:
AKT1
ARNT
AURKA
BECN1
CAV1
CAV3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CRK
CRKL
EGFR
ERBB2
ERBB3
FBXO25
FZR1
GRB14
GRM1
HGF
ITGAV
ITGB3
JAK1
KASH5
KDELR2
LATS2
MAP2K5
MYC
NF2
NHERF1
PDGFA
PDGFB
PDGFC
PDGFRB
PIK3CA
PIK3R1
PLCG1
PLPP6
PRMT5
PTPN11
RAF1
SHB
SHF
SMURF1
SNX2
SNX4
SNX6
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STK11
TERT
TGFBR2
TP53
TTYH2
ULBP2
Entrez ID
5159
5156
HPRD ID
01423
01429
Ensembl ID
ENSG00000113721
ENSG00000134853
Uniprot IDs
P09619
Q59F04
P16234
PDB IDs
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
1GQ5
5GRN
5K5X
6A32
6JOI
6JOJ
6JOK
6JOL
7LBF
7RAM
8PQH
8PQI
8PQJ
8PQK
9GZH
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Epithelial Cell Proliferation
Developmental Process
Cellular Developmental Process
Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Cell Population Proliferation
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Component Organization
Negative Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Cell Differentiation
Animal Organ Development
Negative Regulation Of Cell Differentiation
Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell Migration
Intracellular Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Growth
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Motility
Regulation Of Cell Development
Response To Epidermal Growth Factor
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
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Tagcloud (Intersection)
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