PDGFRB and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 15902258)
0

Data Source:
HPRD (in vivo)

		PDGFRB	PRDX2
Description		platelet derived growth factor receptor beta	peroxiredoxin 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Receptor Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity GTPase Activator Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Angiogenesis Chemotaxis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Cell Migration Involved In Vasculogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib	3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases		Glioma
GWAS		Blood protein levels ( 30072576) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494)	Platelet distribution width ( 32888494)
Interacting Genes		78 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CEP76 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 LCOR NCK1 NCK2 NEDD4 NHERF1 NHERF2 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SNX1 SNX2 SNX27 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TYK2 VAV1 YES1	24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY
Entrez ID		5159	7001
HPRD ID		01423	02763
Ensembl ID		ENSG00000113721	ENSG00000167815
Uniprot IDs		P09619 Q59F04	P32119 V9HW12
PDB IDs		1GQ5 1H9O 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG	1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Adhesion ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Positive Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Insulin Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Programmed Cell Death Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Cell Motility T Cell Activation Cell Activation Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Positive Regulation Of Locomotion Positive Regulation Of T Cell Activation Cell Migration Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Regulation Of Biological Quality	Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process
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