MYOZ1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (pull down)

		MYOZ1	TRIM63
Gene Name		myozenin 1	tripartite motif containing 63, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Actin Cytoskeleton Pseudopodium	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Protein Binding FATZ Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Myofibril Assembly	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTN1 ACTN2 ACTN4 APP BRCA1 FLNC LDB3 MAGEA11 PNKP PRKAA2 TCAP TRIM55 TRIM63	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		58529	84676
HPRD ID		05725	05843
Ensembl ID		ENSG00000177791	ENSG00000158022
Uniprot IDs		B4DUK4 Q9NP98	B4DN95 Q969Q1
PDB IDs			2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Protein Localization To Tight Junction Platelet Activation Cell Junction Assembly Protein Localization To Cell Junction Response To Abiotic Stimulus Actin Filament-based Process Cellular Component Assembly Exocytosis Actin Crosslink Formation Blood Coagulation Hemostasis Response To Stress Striated Muscle Cell Development Muscle Cell Development Secretion By Cell Actin-myosin Filament Sliding Focal Adhesion Assembly Muscle Filament Sliding Intracellular Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cytoskeleton Organization Cell-cell Junction Organization Regulation Of Body Fluid Levels Muscle Contraction Actin Cytoskeleton Organization Wound Healing Striated Muscle Cell Differentiation Secretion Actin-mediated Cell Contraction Tight Junction Assembly Adherens Junction Assembly Muscle System Process Cell Activation Muscle Fiber Development Response To Wounding Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Sarcomere Organization Positive Regulation Of Transporter Activity Actin Filament Organization Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Apoptotic Process Muscle Cell Differentiation Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Apical Junction Assembly Regulation Of Cell Death Positive Regulation Of Ion Transmembrane Transport	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		adapt calcineurin calsarcin calsarcins changing demands disc distances enable fast fiber fibers ko modulates muscles myoblasts myopathic myozenin nfat organism overt rcan1 running sarcomeric skeletal slow striated tightly twitch	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		adapt calcineurin calsarcin calsarcins changing demands disc distances enable fast fiber fibers ko modulates muscles myoblasts myopathic myozenin nfat organism overt rcan1 running sarcomeric skeletal slow striated tightly twitch	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?