MYOZ1 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYOZ1	PLEKHG4
Description		myozenin 1	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Actin Cytoskeleton Z Disc Pseudopodium Cell Projection	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding Actinin Binding FATZ Binding Molecular Condensate Scaffold Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways			RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		42 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FBXL21P FLNA FLNC GOLGA6A GRB2 GSK3B KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		58529	25894
HPRD ID		05725	10890
Ensembl ID		ENSG00000177791	ENSG00000196155
Uniprot IDs		Q9NP98	A0A024R6X4 Q58EX7
PDB IDs		7A8T 7A8U 7ANK
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Muscle Cell Development Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Apoptotic Process Transmembrane Transporter Binding Regulation Of Programmed Cell Death Identical Protein Binding Cytoskeleton Organization Sarcomere Organization Titin Binding Regulation Of Supramolecular Fiber Organization Titin Z Domain Binding Actin Filament Binding Regulation Of Glycolytic Process Cortical Actin Cytoskeleton Sarcomere Regulation Of Amyloid Fibril Formation Regulation Of Generation Of Precursor Metabolites And Energy Platelet Alpha Granule Lumen Regulation Of Carbohydrate Catabolic Process Cytoskeletal Protein Binding Integrin Binding Actin Binding Regulation Of ATP Metabolic Process Regulation Of Cytoskeleton Organization Focal Adhesion Assembly Cytosol Cytoplasm Actin Filament Positive Regulation Of Supramolecular Fiber Organization FATZ Binding Skeletal Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-substrate Junction Assembly Skeletal Muscle Adaptation Striated Muscle Atrophy Prefoldin Complex Cell-substrate Junction Organization Anatomical Structure Morphogenesis Structural Constituent Of Muscle Actomyosin Structure Organization Supramolecular Fiber Organization Organelle Organization Muscle Atrophy Positive Regulation Of Organelle Organization Cell Development	Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation
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