MYOZ1 and LDB3

Number of citations of the paper that reports this interaction (PubMedID 11842093)
0

Data Source:
HPRD (two hybrid, in vivo)

		MYOZ1	LDB3
Description		myozenin 1	LIM domain binding 3
Image
GO Annotations	Cellular Component	Nucleus Actin Cytoskeleton Z Disc Pseudopodium Cell Projection	Stress Fiber Cytoplasm Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding Actinin Binding FATZ Binding Molecular Condensate Scaffold Activity	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Enzyme Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development
Pathways
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		42 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FBXL21P FLNA FLNC GOLGA6A GRB2 GSK3B KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3	7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53
Entrez ID		58529	11155
HPRD ID		05725	16172
Ensembl ID		ENSG00000177791	ENSG00000122367
Uniprot IDs		Q9NP98	A0A0S2Z501 A0A0S2Z530 A0A8I5KV04 O75112 V5T7C5
PDB IDs		7A8T 7A8U 7ANK	1RGW 4YDP
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Muscle Cell Development Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Apoptotic Process Transmembrane Transporter Binding Regulation Of Programmed Cell Death Identical Protein Binding Cytoskeleton Organization Sarcomere Organization Titin Binding Regulation Of Supramolecular Fiber Organization Titin Z Domain Binding Actin Filament Binding Regulation Of Glycolytic Process Cortical Actin Cytoskeleton Sarcomere Regulation Of Amyloid Fibril Formation Regulation Of Generation Of Precursor Metabolites And Energy Platelet Alpha Granule Lumen Regulation Of Carbohydrate Catabolic Process Cytoskeletal Protein Binding Integrin Binding Actin Binding Regulation Of ATP Metabolic Process Regulation Of Cytoskeleton Organization Focal Adhesion Assembly Cytosol Cytoplasm Actin Filament Positive Regulation Of Supramolecular Fiber Organization FATZ Binding Skeletal Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-substrate Junction Assembly Skeletal Muscle Adaptation Striated Muscle Atrophy Prefoldin Complex Cell-substrate Junction Organization Anatomical Structure Morphogenesis Structural Constituent Of Muscle Actomyosin Structure Organization Supramolecular Fiber Organization Organelle Organization Muscle Atrophy Positive Regulation Of Organelle Organization Cell Development	FATZ Binding Telethonin Binding Z Disc Sarcomere Organization Skeletal Muscle Fiber Adaptation Actin Cytoskeleton Actin Binding Actomyosin Structure Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Pseudopodium Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Structural Constituent Of Muscle Molecular Condensate Scaffold Activity Regulation Of DNA-templated Transcription Sarcomere Regulation Of RNA Biosynthetic Process MRNA Transcription Actin Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of RNA Metabolic Process Actin Filament Uncapping Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Skeletal Muscle Tissue Regeneration Actin Filament-based Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Calcium-mediated Signaling Titin Z Domain Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate PML Body Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Striated Muscle Tissue Development Negative Regulation Of RNA Metabolic Process Microspike Assembly Positive Regulation Of Thymocyte Apoptotic Process
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