STX16 and VAMP4

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		STX16	VAMP4
Description		syntaxin 16	vesicle associated membrane protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Endomembrane System Membrane Synaptic Vesicle Membrane SNARE Complex Golgi Cisterna Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Bounding Membrane Of Organelle Presynaptic Endosome Membrane Glutamatergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle Docking	Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Cellular Response To Type II Interferon Golgi Ribbon Formation Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Synaptic Vesicle Endocytosis
Pathways		Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Pseudohypoparathyroidism
GWAS		Cardiovascular risk factors (age interaction) ( 20838585) Hemoglobin ( 32888494)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		12 interacting genes: MEOX2 NAPB PTPN12 RHOU STX1A STX2 STX4 STX6 VAMP3 VAMP4 VPS45 VTI1A	50 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 BIK CD79A CFTR CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 HSD17B13 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SCN3B SEC11C SLC10A6 SLC35H1 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54
Entrez ID		8675	8674
HPRD ID		04718	06070
Ensembl ID		ENSG00000124222	ENSG00000117533
Uniprot IDs		B4DJX9 O14662	O75379 Q6IAZ3
PDB IDs		8QQF
Enriched GO Terms of Interacting Partners?		SNARE Complex SNAP Receptor Activity Organelle Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion SNARE Complex Assembly Vesicle Docking SNARE Binding Membrane Fusion Vesicle Organization Intracellular Protein Transport Organelle Localization By Membrane Tethering Membrane Docking Protein Transport Intracellular Transport Endomembrane System Establishment Of Protein Localization Membrane Organization Cellular Localization Establishment Of Localization In Cell Phagocytic Vesicle Intracellular Protein Localization Trans-Golgi Network Membrane Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport To The Plasma Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Cornified Envelope Assembly Endosome Exocytosis Organelle Localization Cellular Response To Type II Interferon Endocytic Recycling Clathrin-coated Vesicle Regulation Of Synaptic Vesicle Priming Localization Within Membrane Endosomal Transport Glutamatergic Synapse Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Response To Type II Interferon Post-Golgi Vesicle-mediated Transport Golgi Membrane Bounding Membrane Of Organelle Cytosolic Transport Synaptic Vesicle Organelle Organization Secretion By Cell Presynaptic Active Zone Membrane Calcium-ion Regulated Exocytosis	Membrane SNARE Binding SNARE Complex Vesicle Docking Endoplasmic Reticulum Membrane Organelle Localization By Membrane Tethering Endoplasmic Reticulum SNAP Receptor Activity Membrane Docking Glutathione Peroxidase Activity Synaptic Vesicle Membrane Protein Binding Steroid Biosynthetic Process Synaptic Vesicle Exocytosis Cholesterol Biosynthetic Process Chloride Channel Inhibitor Activity Unsaturated Fatty Acid Metabolic Process ATP-dependent Protein Binding Mitochondrial Membrane Vesicle Fusion Chromaffin Granule Membrane Sterol Biosynthetic Process Organelle Membrane Fusion Small Molecule Biosynthetic Process Vesicle Organization Mitochondrial Outer Membrane Syntaxin Binding Vesicle-mediated Transport SNARE Complex Assembly Organelle Fusion Intracellular Protein Transport Endomembrane System Membrane Fusion
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