ZFAND2B and TARDBP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZFAND2B	TARDBP
Description		zinc finger AN1-type containing 2B	TAR DNA binding protein
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GO Annotations	Cellular Component	Proteasome Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Chromatin Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule
	Molecular Function	Protein Binding Zinc Ion Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Lipid Binding Identical Protein Binding Pre-mRNA Intronic Binding Molecular Condensate Scaffold Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Targeting To ER	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Host-mediated Suppression Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization Amyloid Fibril Formation
Pathways
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) White blood cell count ( 32888494)	Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)
Interacting Genes		6 interacting genes: DAZAP2 RHOU TARDBP UBC UBQLN1 UBQLN2	18 interacting genes: APP ARHGEF28 EXOSC10 FBXO7 IRAK2 LONRF2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF126 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1
Entrez ID		130617	23435
HPRD ID		11234	05466
Ensembl ID		ENSG00000158552	ENSG00000120948
Uniprot IDs		A0A087X0D9 Q8WV99	Q13148 Q9H256
PDB IDs		1X4V	1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B 7KWZ 7N9H 7PY2 7Q3U 8A6I 8CG3 8CGG 8CGH 8QX9 8QXA 8QXB 9FOF 9FOR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Molecular Condensate Scaffold Activity Cytoplasmic Stress Granule Nuclear Inner Membrane Organization Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Proteolysis Involved In Protein Catabolic Process Identical Protein Binding Organelle Assembly Interchromatin Granule Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Perichromatin Fibrils Regulation Of Macroautophagy Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Focal Adhesion Disassembly Endosome Membrane Macromolecule Catabolic Process Ubiquitin Protein Ligase Binding Host-mediated Suppression Of Viral Transcription Pre-mRNA Intronic Binding Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Aggrephagy Proteolysis Protein Tag Activity Organelle Organization Mitogen-activated Protein Kinase Kinase Kinase Binding Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization 3'-UTR-mediated MRNA Destabilization Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Stability	Macromolecule Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Protein Heterodimerization Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Proteasomal Protein Catabolic Process Ubiquitin Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Ubiquitin Ligase Complex Negative Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process MRNA Catabolic Process Protein Ubiquitination Protein Catabolic Process 3'-5'-RNA Exonuclease Activity Regulation Of Metabolic Process Catabolic Process Zinc Ion Binding Ubiquitin Protein Ligase Activity Aggresome Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Cytoplasm Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Regulation Of Macromolecule Metabolic Process RNA Catabolic Process Exonuclease Activity
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