AP1S1 and AP1G1

Number of citations of the paper that reports this interaction (PMID 10535737)
150

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD (two hybrid)

		AP1S1	AP1G1
Gene Name		adaptor-related protein complex 1, sigma 1 subunit	adaptor-related protein complex 1, gamma 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Coated Pit Membrane AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Transporter Activity	Transporter Activity Protein Binding Protein Transporter Activity Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Virus Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Membrane Organization Golgi To Lysosome Transport
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AP1G1 AP1G2 AP1M2 AP2A2	20 interactors: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 CLINT1 CLTC DNER KIF13A MAP1A RAB5A RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		1174	164
HPRD ID		04635	04637
Ensembl ID		ENSG00000106367	ENSG00000166747
Uniprot IDs		P61966	O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Viral Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Cellular Localization Positive Regulation Of Natural Killer Cell Degranulation Golgi To Lysosome Transport Regulation Of Immune System Process Golgi Vesicle Transport Golgi To Vacuole Transport Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Transport Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Regulated Secretory Pathway Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Activation Clathrin-mediated Endocytosis Regulation Of Regulated Secretory Pathway Vesicle Targeting Membrane Organization Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Pigmentation Positive Regulation Of Exocytosis Developmental Pigmentation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Ephrin Receptor Signaling Pathway	Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein Localization Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Localization In Cell Endocytosis Cellular Localization Regulation Of Defense Response To Virus Transport Establishment Of Vesicle Localization Intracellular Protein Transport Vesicle Localization Cellular Protein Localization Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Establishment Of Organelle Localization Organelle Localization Vesicle Targeting Vesicle Organization Viral Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Nucleation Vesicle Targeting, To, From Or Within Golgi Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Immune System Process Regulation Of Endocytosis Synaptic Vesicle Recycling Receptor Internalization Endosomal Transport Negative Regulation Of Kit Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Immune System Process Vesicle Targeting, Trans-Golgi To Endosome Synaptic Vesicle Membrane Organization Regulation Of Synaptic Transmission Membrane Budding Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Endosome Size Regulation Of Opioid Receptor Signaling Pathway
Tagcloud ?		actb api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 ppp2r5b primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
Tagcloud (Difference) ?		actb api5 calculating crossbred csn1s2 fabp3 gilts icg lactation ltf mined mrpl39 mtg1 normalization parturition pcsk2 ppp2r5b primiparous ptbp1 qpcr qtrt1 rps15a scd tmem24 trim41 underscore uxt vabp vapb
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