ARHGEF25 and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 20395553)
46

Data Source:
BioGRID (pull down)

		ARHGEF25	PRKCG
Description		Rho guanine nucleotide exchange factor 25	protein kinase C gamma
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Myofibril Sarcomere	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		G alpha (q) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs			Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Systolic blood pressure ( 30224653 30578418)
Interacting Genes		5 interacting genes: CDC42 PRKCG RAC1 RHOA RHOU	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		115557	5582
HPRD ID		13573	01502
Ensembl ID		ENSG00000240771	ENSG00000126583
Uniprot IDs		Q86VW2	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs		2RGN	2E73 2UZP
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly GTPase Activity G Protein Activity Regulation Of Cell-substrate Junction Organization GTP Binding Actin Cytoskeleton Organization Establishment Of Cell Polarity Actin Filament-based Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Focal Adhesion Cell Projection Protein Kinase Binding Dendrite Thioesterase Binding Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Nucleotide Binding Cell-cell Junction Organization Intracellular Signal Transduction Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Postsynapse Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Intracellular Signaling Cassette Establishment Of Epithelial Cell Polarity Phagocytosis, Engulfment Regulation Of Actin Filament Organization Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Cytoskeleton Organization Regulation Of Synapse Organization Regulation Of Cellular Component Organization Telencephalon Cell Migration	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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