ARHGEF25

Gene Name		Rho guanine nucleotide exchange factor (GEF) 25
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Myofibril Sarcomere
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Positive Regulation Of Rho GTPase Activity
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CDC42 PRKCG RAC1 RHOA
Entrez ID		115557
HPRD ID		13573
Ensembl ID		ENSG00000240771
Uniprot IDs		Q86VW2
PDB IDs		2RGN
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cellular Component Biogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Positive Regulation Of Cytokinesis Axon Guidance Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Neural Nucleus Development Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Cytokinesis Regulation Of Lipid Kinase Activity Positive Regulation Of Cell Development Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Stress Fiber Assembly Axonogenesis Positive Regulation Of DNA Replication Axon Development Cellular Response To Growth Factor Stimulus T Cell Costimulation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Midbrain Development Neuron Projection Morphogenesis Actin Filament-based Process Nervous System Development Cell Activation
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