SMTN and BRMS1

Number of citations of the paper that reports this interaction (PMID 16919237)
26

Data Source:
HPRD (two hybrid)

		SMTN	BRMS1
Gene Name		smoothelin	breast cancer metastasis suppressor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Actin Binding Structural Constituent Of Muscle	Histone Deacetylase Activity Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Smooth Muscle Contraction Muscle Organ Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		2 interactors: ACTA1 BRMS1	36 interactors: APP ARID4A BRMS1L CEP70 DNAJB1 DNAJB6 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 ING1 KPNA5 LINC00152 LRIF1 NMI PFDN5 RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNX6 SPOP SUDS3 TAF1 UBE2D1
Entrez ID		6525	25855
HPRD ID		03675	05879
Ensembl ID		ENSG00000183963	ENSG00000174744
Uniprot IDs		B4DI56 B4E229 P53814	G5E9I4 Q9HCU9
PDB IDs		2D87	2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Fiber Adaptation Positive Regulation Of Anoikis Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Skeletal Muscle Adaptation Regulation Of Anoikis Skeletal Muscle Fiber Development Positive Regulation Of Protein Deacetylation Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Muscle Fiber Development Regulation Of Protein Deacetylation Myotube Differentiation Actin Filament-based Movement Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Deacetylation Protein Deacetylation Myofibril Assembly	Chromatin Organization Chromatin Modification Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Protein Deacetylation Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Chromosome Organization Negative Regulation Of Biosynthetic Process Histone Modification Negative Regulation Of Cellular Metabolic Process Organelle Organization Negative Regulation Of Gene Expression, Epigenetic Histone H4 Deacetylation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Histone H3 Deacetylation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression Cellular Response To Heat Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Remodeling Positive Regulation Of Macromolecule Biosynthetic Process Response To Heat Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process ATP-dependent Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process
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