MAP4K3 and SORBS1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MAP4K3	SORBS1
Description		mitogen-activated protein kinase kinase kinase kinase 3	sorbin and SH3 domain containing 1
Image
GO Annotations	Cellular Component	Cytoplasm	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane
Pathways			Smooth Muscle Contraction
Drugs		Fostamatinib
Diseases
GWAS		Bone mineral density ( 31790847)	Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		9 interacting genes: ACE2 BIN1 COPS5 ITSN2 PPP2CA SH3GL2 SH3RF1 SORBS1 STRN4	31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL
Entrez ID		8491	10580
HPRD ID		05373	05587
Ensembl ID		ENSG00000011566	ENSG00000095637
Uniprot IDs		A8K602 B3KMM5 B4DSS3 F5H5A3 Q8IVH8	A0A3B3IRW8 B4DTX5 Q9BX66
PDB IDs		5J5T	2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse FAR/SIN/STRIPAK Complex Endocytosis Negative Regulation Of Hippo Signaling Import Into Cell Vesicle-mediated Transport Tau Protein Binding Regulation Of Hippo Signaling Membrane Raft Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction Negative Regulation Of Signal Transduction Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Signaling RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Negative Regulation Of Signaling Macrophage Migration Inhibitory Factor Binding Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Synapse Regulation Of Striated Muscle Contraction Negative Regulation Of Blood-brain Barrier Permeability Entry Receptor-mediated Virion Attachment To Host Cell Cytoplasm Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Exosomal Secretion Viral Translation Viral Life Cycle Regulation Of Macromolecule Metabolic Process Synaptic Vesicle Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Action Potential Positive Regulation Of Cellular Component Biogenesis Regulation Of Generation Of Precursor Metabolites And Energy	SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone
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