MAP4K3 and COPS5

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAP4K3	COPS5
Gene Name		mitogen-activated protein kinase kinase kinase kinase 3	COP9 signalosome subunit 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction Regulation Of Catalytic Activity	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BIN1 COPS5 GRB2 ITSN2 SH3GL2 SH3RF1 SORBS1	90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG
Entrez ID		8491	10987
HPRD ID		05373	06888
Ensembl ID		ENSG00000011566	ENSG00000121022
Uniprot IDs		A8K602 B3KMM5 Q8IVH8	Q92905
PDB IDs			4F7O
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Regulation Of Signal Transduction Endocytosis Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Metabolic Process Transport Regulation Of MAPK Cascade Lipid Tube Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of JNK Cascade ERBB Signaling Pathway Positive Regulation Of Metabolic Process Exosomal Secretion Regulation Of Stress-activated MAPK Cascade Regulation Of Endocytosis Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Cullin Deneddylation Negative Regulation Of Signal Transduction Positive Regulation Of Astrocyte Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Response To Insulin Protein Deneddylation Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Glycogen Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Vesicle-mediated Transport Protein-lipid Complex Assembly Axon Guidance Labyrinthine Layer Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Response To Peptide Hormone Cellular Response To Organonitrogen Compound Positive Regulation Of Protein Localization To Plasma Membrane Generation Of Neurons	Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Difference) ?		candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Intersection) ?