MAP4K3 and PPP2CA

Number of citations of the paper that reports this interaction (PubMedID 32640226)
55

Data Source:
BioGRID (pull down)

		MAP4K3	PPP2CA
Description		mitogen-activated protein kinase kinase kinase kinase 3	protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Cytoplasm	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Spindle Pole Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex INTAC Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
	Biological Process	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Mesoderm Development Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Polymerization Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Meiotic Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Fostamatinib	Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS		Bone mineral density ( 31790847)
Interacting Genes		9 interacting genes: ACE2 BIN1 COPS5 ITSN2 PPP2CA SH3GL2 SH3RF1 SORBS1 STRN4	101 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAP4K1 MAP4K3 MAP4K4 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 POLR2A PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 UBC VAC14 VDR XRN1 YPEL3
Entrez ID		8491	5515
HPRD ID		05373	08912
Ensembl ID		ENSG00000011566	ENSG00000113575
Uniprot IDs		A8K602 B3KMM5 B4DSS3 F5H5A3 Q8IVH8	B3KQ51 B3KUN1 P67775
PDB IDs		5J5T	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 4NY3 5W0W 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse FAR/SIN/STRIPAK Complex Endocytosis Negative Regulation Of Hippo Signaling Import Into Cell Vesicle-mediated Transport Tau Protein Binding Regulation Of Hippo Signaling Membrane Raft Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction Negative Regulation Of Signal Transduction Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Signaling RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Negative Regulation Of Signaling Macrophage Migration Inhibitory Factor Binding Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Synapse Regulation Of Striated Muscle Contraction Negative Regulation Of Blood-brain Barrier Permeability Entry Receptor-mediated Virion Attachment To Host Cell Cytoplasm Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Exosomal Secretion Viral Translation Viral Life Cycle Regulation Of Macromolecule Metabolic Process Synaptic Vesicle Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Action Potential Positive Regulation Of Cellular Component Biogenesis Regulation Of Generation Of Precursor Metabolites And Energy	Signal Transduction Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Cytosol Regulation Of Cell Population Proliferation Protein Phosphatase Regulator Activity Protein Phosphorylation Protein Phosphatase Type 2A Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Apoptotic Process Regulation Of Cell Cycle Programmed Cell Death Cell Death Protein Phosphatase 2A Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cytoplasm Nucleus Response To Ketone Response To Lipid Regulation Of Mitotic Cell Cycle Response To Starvation Positive Regulation Of Intracellular Signal Transduction Protein Modification Process Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Identical Protein Binding Positive Regulation Of Apoptotic Process Cellular Response To Stress Protein Metabolic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound
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