MAP3K12 and FRA10AC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		MAP3K12	FRA10AC1
Description		mitogen-activated protein kinase kinase kinase 12	FRA10A associated CGG repeat 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Protein Binding Phosphatase Activity
	Biological Process	Protein Phosphorylation JNK Cascade Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	MRNA Splicing, Via Spliceosome
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	27 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D GATD3 GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		7786	118924
HPRD ID		02709	12319
Ensembl ID		ENSG00000139625	ENSG00000148690
Uniprot IDs		Q12852	Q70Z53
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2 8DEG 8OUR 8OUS 8OUT 9CDX 9CDY
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Programmed Cell Death MAP-kinase Scaffold Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling JUN Kinase Kinase Activity Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Mitogen-activated Protein Kinase Kinase Binding JUN Kinase Binding Cytosol Protein Kinase Activity Intracellular Signal Transduction Regulation Of Motor Neuron Apoptotic Process MAP Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAP Kinase Activity Regulation Of CD8-positive, Alpha-beta T Cell Activation Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Serine Kinase Activity Signal Transduction Perinuclear Region Of Cytoplasm Protein Serine/threonine Kinase Activity Transferase Activity Protein Kinase Binding Kinesin Binding Protein Kinase Inhibitor Activity Multivesicular Body, Internal Vesicle Lumen Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity	RNA Splicing MRNA Processing U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Nuclear Speck Spliceosomal Complex Nucleic Acid Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Cajal Body Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome U2-type Spliceosomal Complex Glycerophosphoinositol Inositolphosphodiesterase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Nucleus Nucleic Acid Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?