MAP3K12 and FTL

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAP3K12	FTL
Description		mitogen-activated protein kinase kinase kinase 12	ferritin light chain
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation JNK Cascade Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	Iron Ion Transport Intracellular Iron Ion Homeostasis
Pathways			Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs		Fostamatinib	Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17
Entrez ID		7786	2512
HPRD ID		02709	00616
Ensembl ID		ENSG00000139625	ENSG00000087086
Uniprot IDs		Q12852	A0A384MDR3 P02792
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2 8DEG 8OUR 8OUS 8OUT 9CDX 9CDY	2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Programmed Cell Death MAP-kinase Scaffold Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling JUN Kinase Kinase Activity Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Mitogen-activated Protein Kinase Kinase Binding JUN Kinase Binding Cytosol Protein Kinase Activity Intracellular Signal Transduction Regulation Of Motor Neuron Apoptotic Process MAP Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAP Kinase Activity Regulation Of CD8-positive, Alpha-beta T Cell Activation Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Serine Kinase Activity Signal Transduction Perinuclear Region Of Cytoplasm Protein Serine/threonine Kinase Activity Transferase Activity Protein Kinase Binding Kinesin Binding Protein Kinase Inhibitor Activity Multivesicular Body, Internal Vesicle Lumen Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity
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