MAP3K12 and RGS1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAP3K12	RGS1
Description		mitogen-activated protein kinase kinase kinase 12	regulator of G protein signaling 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Protein Phosphorylation JNK Cascade Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway
Pathways			G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Celiac disease ( 18311140 20190752 22057235 30572963) Multiple sclerosis ( 21833088 24076602 27386562) Systemic lupus erythematosus ( 28714469 33536424) Systemic vasculitis ( 29374629) Type 1 diabetes ( 34127860)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	9 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 TSC22D1 UTP14A
Entrez ID		7786	5996
HPRD ID		02709	15968
Ensembl ID		ENSG00000139625	ENSG00000090104
Uniprot IDs		Q12852	Q08116
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2 8DEG 8OUR 8OUS 8OUT 9CDX 9CDY	2BV1 2GTP
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Programmed Cell Death MAP-kinase Scaffold Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling JUN Kinase Kinase Activity Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Mitogen-activated Protein Kinase Kinase Binding JUN Kinase Binding Cytosol Protein Kinase Activity Intracellular Signal Transduction Regulation Of Motor Neuron Apoptotic Process MAP Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAP Kinase Activity Regulation Of CD8-positive, Alpha-beta T Cell Activation Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Serine Kinase Activity Signal Transduction Perinuclear Region Of Cytoplasm Protein Serine/threonine Kinase Activity Transferase Activity Protein Kinase Binding Kinesin Binding Protein Kinase Inhibitor Activity Multivesicular Body, Internal Vesicle Lumen Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity	Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Ethanolamine Metabolic Process Glycerophosphoinositol Glycerophosphodiesterase Activity G Protein-coupled Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell Body Lipoprotein Particle Positive Regulation Of Signal Transduction Positive Regulation Of Protein Import Defense Response To Gram-negative Bacterium Mu-type Opioid Receptor Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lewy Body Core Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Corticotropin-releasing Hormone Receptor 1 Binding
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