PTMA and KEAP1

Number of citations of the paper that reports this interaction (PMID 23318954)
3

Data Source:
BioGRID (two hybrid, pull down, unspecified method, x-ray crystallography)

		PTMA	KEAP1
Gene Name		prothymosin, alpha	kelch-like ECH-associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Transcription Factor Binding
	Biological Process	Transcription, DNA-templated	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		41 interactors: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 HDAC1 HDAC2 HIST1H1A HIST1H2AJ HIST1H2BG HIST1H4A HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17	38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32
Entrez ID		5757	9817
HPRD ID		01778	12079
Ensembl ID		ENSG00000187514	ENSG00000079999
Uniprot IDs		P06454 Q53S24	Q14145
PDB IDs		2L9I	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Organelle Organization DNA Metabolic Process Chromatin Modification Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Histone Modification DNA Packaging Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Protein Complex Assembly Response To Stimulus Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression DNA Replication Viral Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Homeostatic Process Regulation Of Protein Metabolic Process Rhythmic Process Regulation Of Chromosome Organization G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Nucleosome Assembly Regulation Of RNA Metabolic Process Cell Cycle Process Cellular Response To Stress Regulation Of Cell Death Chromatin Assembly	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing
Tagcloud ?		adjacent advanced ajcc assessment colon crc depth dfs distant help hence invasion lnm lymph metastasis mutant node os overexpression plays predict prognosis prothymosin survival tissue tp53 translational triggers tumorigenesis	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?		adjacent advanced ajcc assessment colon crc depth dfs distant help hence invasion lnm lymph metastasis mutant node os overexpression plays predict prognosis prothymosin survival tissue tp53 translational triggers tumorigenesis	acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?