Wiki-Pi
About
Search
People
Updates
Search
PTMA and IL7R
Number of citations of the paper that reports this interaction (PubMedID
23151878
)
60
Data Source:
BioGRID
(unspecified method)
PTMA
IL7R
Description
prothymosin alpha
interleukin 7 receptor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
Protein Binding
Histone Binding
DNA-binding Transcription Factor Binding
Histone Chaperone Activity
Antigen Binding
Cytokine Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Biological Process
Chromatin Organization
DNA-templated Transcription
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Recombination
Cell Morphogenesis
B Cell Homeostasis
T Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Size
Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Hemopoiesis
T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-7-mediated Signaling Pathway
B Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Lymph Node Development
Defense Response To Gram-positive Bacterium
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Lymphocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
27863252
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29785011
29083406
)
Allergic rhinitis (
31361310
30013184
)
Ankylosing spondylitis (
23749187
)
Asthma (
34103634
32296059
31619474
31361310
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Eczema (
31361310
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
21244703
19525953
21833088
24076602
)
Neutrophil percentage of white cells (
27863252
32888494
)
Primary biliary cholangitis (
26394269
21399635
30643196
23000144
28062665
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
25751624
17554260
)
Ulcerative colitis (
21297633
)
White blood cell count (
32888494
)
Interacting Genes
43 interacting genes:
CASP3
CASP7
CCNA2
CCNB1
CDK1
CDK2
CDK4
CREBBP
EP300
ESR1
FNDC3B
GSK3A
H1-1
H2AC14
H2BC21
H2BC8
H3-4
H3C14
H4C1
H4C14
HDAC1
HDAC2
HSPA1A
IL7R
KEAP1
KPNA2
KPNB1
NCOR1
NUP62
NUPR1
NUTF2
PCNA
PHB2
RAN
RCC1
SET
SIN3A
STAT3
TERF1
TERF2
TERF2IP
VIPR1
ZDHHC17
110 interacting genes:
AGTRAP
ALYREF
APOL3
CIRBP
CPSF1
CRLF2
DDX21
DDX39B
DDX3X
DDX5
DHX36
DHX9
EIF2AK2
ELAVL1
EMG1
FAU
FUS
FYN
G3BP1
H1-10
H1-2
H1-4
H2BC21
HNRNPA0
HNRNPA3
HNRNPAB
HNRNPC
HNRNPD
HNRNPDL
HNRNPH3
HNRNPL
HNRNPR
HNRNPU
HNRNPUL1
HNRNPUL2
IL2RG
IL7
ILF2
ILF3
JAK1
JAK3
KIT
LYN
MALL
MAP4
MS4A1
NCL
NONO
PABPC1
PABPC4
PABPN1
PIK3R1
PTBP1
PTK2B
PTMA
PURA
PURB
QKI
RACK1
RAD21
RBM3
RBMX
RPL15
RPL18
RPL22
RPL29
RPL30
RPL31
RPL6
RPL7
RPL8
RPS20
RPS3
RPSA
RRAGA
RSL1D1
SAFB
SDC4
SF1
SF3A1
SF3B1
SNRNP70
SNRPA
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SRP14
SRP9
SRSF3
SRSF9
SSB
STAT3
STAT5A
STAT5B
SYNCRIP
TMEM120B
TOE1
TOP1
TSLP
U2AF1
U2AF2
YBX1
YBX3
YWHAE
YWHAG
ZNF787
Entrez ID
5757
3575
HPRD ID
01778
00893
Ensembl ID
ENSG00000187514
ENSG00000168685
Uniprot IDs
P06454
Q53S24
P16871
PDB IDs
2L9I
2MNQ
3DI2
3DI3
3UP1
5J11
6P50
6P67
7OPB
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Chromatin Organization
Chromatin Remodeling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Chromosome, Telomeric Region
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Binding
Protein Localization To Organelle
Chromosome Organization
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleosome Assembly
Protein-containing Complex
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Import Into Nucleus
Rhythmic Process
Negative Regulation Of Biosynthetic Process
Chromosome
Import Into Nucleus
Telomere Organization
Protein-DNA Complex Assembly
Nucleosome Organization
Regulation Of Macromolecule Biosynthetic Process
Structural Constituent Of Chromatin
Nuclear Telomere Cap Complex
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
Protein Localization To Chromosome
Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Nucleosome
Positive Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Chromatin
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Population Proliferation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Programmed Cell Death
DNA Binding
RNA Binding
Ribonucleoprotein Complex
Nucleic Acid Binding
RNA Processing
MRNA Processing
RNA Splicing
Spliceosomal Complex
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
MRNA Binding
Nucleus
Catalytic Step 2 Spliceosome
Nucleic Acid Metabolic Process
Regulation Of MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of MRNA Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of RNA Catabolic Process
Positive Regulation Of Gene Expression
Cytoplasmic Translation
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Spliceosomal Complex Assembly
Regulation Of Translation
MRNA Stabilization
Regulation Of MRNA Processing
U4 SnRNP
U1 SnRNP
7-methylguanosine Cap Hypermethylation
U12-type Spliceosomal Complex
U2-type Prespliceosome Assembly
Cytosolic Ribosome
Regulation Of RNA Splicing
Negative Regulation Of Translation
U2 SnRNP
Positive Regulation Of Translation
Ribosome
Positive Regulation Of Cytoplasmic Translation
Regulation Of MRNA Stability
U2-type Spliceosomal Complex
Protein-RNA Complex Assembly
Methylosome
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of RNA Stability
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?