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PTMA and CCNB1
Number of citations of the paper that reports this interaction (PubMedID
11310559
)
0
Data Source:
HPRD
(in vitro)
PTMA
CCNB1
Description
prothymosin alpha
cyclin B1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Membrane
Cyclin B1-CDK1 Complex
Molecular Function
Protein Binding
Histone Binding
DNA-binding Transcription Factor Binding
Histone Chaperone Activity
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Chromatin Organization
DNA-templated Transcription
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Mitotic Spindle Organization
Mitotic Metaphase Chromosome Alignment
Spermatogenesis
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Toxic Substance
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of MRNA 3'-end Processing
Tissue Regeneration
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerization of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Nuclear events stimulated by ALK signaling in cancer
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Lymphocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
27863252
32888494
)
Interacting Genes
43 interacting genes:
CASP3
CASP7
CCNA2
CCNB1
CDK1
CDK2
CDK4
CREBBP
EP300
ESR1
FNDC3B
GSK3A
H1-1
H2AC14
H2BC21
H2BC8
H3-4
H3C14
H4C1
H4C14
HDAC1
HDAC2
HSPA1A
IL7R
KEAP1
KPNA2
KPNB1
NCOR1
NUP62
NUPR1
NUTF2
PCNA
PHB2
RAN
RCC1
SET
SIN3A
STAT3
TERF1
TERF2
TERF2IP
VIPR1
ZDHHC17
64 interacting genes:
ANAPC11
ARID4A
BRCA1
BTG2
CCNB1IP1
CCNF
CDC25A
CDC25C
CDC34
CDC6
CDH1
CDK1
CDKN1A
CDKN1B
CDT1
CEBPA
CSNK2B
CUX1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
KPNB1
MAP4
MEF2C
MOK
NACC1
OGT
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
PRC1
PRKDC
PTCH1
PTMA
RALBP1
RB1
RUNX2
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2D2
UBE2N
UBE3C
UBE3D
UCHL3
USP39
WEE1
XIAP
XRCC6
ZFAND5
Entrez ID
5757
891
HPRD ID
01778
00454
Ensembl ID
ENSG00000187514
ENSG00000134057
Uniprot IDs
P06454
Q53S24
P14635
PDB IDs
2L9I
2MNQ
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
7NJ0
8TAR
8TAU
9FH9
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Chromatin Organization
Chromatin Remodeling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Chromosome, Telomeric Region
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Binding
Protein Localization To Organelle
Chromosome Organization
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleosome Assembly
Protein-containing Complex
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Import Into Nucleus
Rhythmic Process
Negative Regulation Of Biosynthetic Process
Chromosome
Import Into Nucleus
Telomere Organization
Protein-DNA Complex Assembly
Nucleosome Organization
Regulation Of Macromolecule Biosynthetic Process
Structural Constituent Of Chromatin
Nuclear Telomere Cap Complex
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
Protein Localization To Chromosome
Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Nucleosome
Positive Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Gene Expression
Chromatin
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Population Proliferation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Programmed Cell Death
DNA Binding
Regulation Of Cell Cycle
Nucleoplasm
Nucleus
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Replication
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of DNA Replication
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Modification Process
Signal Transduction In Response To DNA Damage
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Phosphorylation
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Cell Division
DNA Metabolic Process
Regulation Of Protein Kinase Activity
Negative Regulation Of DNA Metabolic Process
Cyclin Binding
Regulation Of Kinase Activity
DNA Damage Response
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
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