PTMA and SIN3A

Number of citations of the paper that reports this interaction (PubMedID 12634383)
41

Data Source:
HPRD (in vitro)

		PTMA	SIN3A
Description		prothymosin alpha	SIN3 transcription regulator family member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Transcription Repressor Complex Protein-containing Complex Sin3-type Complex
	Molecular Function	Protein Binding Histone Binding DNA-binding Transcription Factor Binding Histone Chaperone Activity	DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Chromatin Organization DNA-templated Transcription Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Intracellular Protein Localization Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebral Cortex Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Heterochromatin Formation Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Response To Methylglyoxal Type I Interferon-mediated Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine
Pathways			SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)	Caffeine consumption from tea ( 33287642) Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)
Interacting Genes		43 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 FNDC3B GSK3A H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17	101 interacting genes: ARID4A ARID4B ATM BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CEBPA CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 DMRTC1B ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB1 PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 TSN ZBTB16
Entrez ID		5757	25942
HPRD ID		01778	09690
Ensembl ID		ENSG00000187514	ENSG00000169375
Uniprot IDs		P06454 Q53S24	Q96ST3
PDB IDs		2L9I 2MNQ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromatin Organization Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Protein Localization To Organelle Chromosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Protein-containing Complex Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Import Into Nucleus Rhythmic Process Negative Regulation Of Biosynthetic Process Chromosome Import Into Nucleus Telomere Organization Protein-DNA Complex Assembly Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Nuclear Telomere Cap Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleosome Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Programmed Cell Death DNA Binding	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sin3-type Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Remodeling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process
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