SEMA6A and ITSN2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEMA6A	ITSN2
Description		semaphorin 6A	intersectin 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon	Cytoplasm Centrosome Cytosol Plasma Membrane Presynaptic Membrane Extracellular Exosome Intracellular Vesicle
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration	Endocytosis Endosomal Transport Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		Other semaphorin interactions	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Body mass index ( 27296613) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Subcortical volume (MOSTest) ( 32665545) Wegener's granulomatosis ( 23740775)	Appendicular lean mass ( 33097823) Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Sjögren's syndrome ( 24097067) Total cholesterol levels ( 33339817)
Interacting Genes		6 interacting genes: EVL ITSN2 SH3RF1 SORBS1 SORBS2 UBE2I	74 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SNCA SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		57556	50618
HPRD ID		06906	09193
Ensembl ID		ENSG00000092421	ENSG00000198399
Uniprot IDs		A0A0A0MQU6 Q9H2E6	A6H8W8 Q9NZM3
PDB IDs		6WTS	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?		Lamellipodium	SH3 Domain Binding Endocytosis Cell Projection Vesicle-mediated Transport Actin Filament-based Movement Import Into Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cytoplasm Synaptic Vesicle Endocytosis Organelle Localization Glutamatergic Synapse Presynaptic Endocytosis Actin Binding Vesicle-mediated Transport In Synapse Organelle Organization Supramolecular Fiber Organization Cadherin Binding Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cellular Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Membrane Organization MRNA Binding Protein Complex Oligomerization Regulation Of Vesicle-mediated Transport Regulation Of Angiotensin-activated Signaling Pathway Intracellular Transport Apical Constriction Positive Regulation Of RNA Export From Nucleus Cellular Component Assembly Cytosol Actin Cytoskeleton Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cell-cell Signaling Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission
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