SEMA6A and SORBS2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEMA6A	SORBS2
Gene Name		sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	sorbin and SH3 domain containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon	Nucleus Plasma Membrane Actin Cytoskeleton Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Structural Constituent Of Muscle Protein Domain Specific Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Organ Morphogenesis	Actin Filament Organization Cell Adhesion Biological_process Cell Migration
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Wegener's granulomatosis ( 23740775)	Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		6 interactors: EVL ITSN2 SH3RF1 SORBS1 SORBS2 SUMO1	35 interactors: ABL1 ABL2 ACTN1 ADAM15 AKT1 AKT2 ATPAF2 CBL DLGAP1 DLGAP2 DLGAP4 EFS EGFR FLOT1 MDM2 MLLT4 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SYNJ1 TRAF4 VCL VPS37C WAS WASF1 YWHAE YWHAZ
Entrez ID		57556	8470
HPRD ID		06906	12473
Ensembl ID		ENSG00000092421	ENSG00000154556
Uniprot IDs		Q9H2E6	B7Z3D7 B7Z997 O94875
PDB IDs			4IGZ
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Protein Complex Assembly PML Body Organization Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Negative Regulation Of Ruffle Assembly Cytoskeleton Organization	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Movement Signaling Positive Regulation Of Transport Cell Communication Positive Regulation Of Organelle Organization Programmed Cell Death Regulation Of Cell Motility Cell Death Death Protein Autophosphorylation Regulation Of Cellular Component Organization Cell Activation Regulation Of Locomotion Regulation Of Cellular Ketone Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Regulation Of Signaling Axonogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Localization Regulation Of Signal Transduction Apoptotic Process Regulation Of Oxidoreductase Activity Cell Development Axon Development Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Localization Regulation Of Intracellular Transport Neuron Projection Development Innate Immune Response Actin Filament Organization Neuron Projection Morphogenesis Neurogenesis Positive Regulation Of Oxidoreductase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Projection Organization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Cell Adhesion Movement Of Cell Or Subcellular Component Neuron Development Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 srgn trem2 tubal3 txnrd1
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 srgn trem2 tubal3 txnrd1
Tagcloud (Intersection) ?