NLGN2 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 9278515)
0

Data Source:
BioGRID (two hybrid)

		NLGN2	DLG3
Description		neuroligin 2	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Dendritic Shaft Synapse Postsynaptic Membrane Excitatory Synapse Inhibitory Synapse Ribbon Synapse Glycinergic Synapse Dopaminergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Postsynaptic Specialization Membrane	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Thigmotaxis Regulation Of Respiratory Gaseous Exchange By Nervous System Process Cell Adhesion Neuron Cell-cell Adhesion Synapse Assembly Jump Response Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Cell Surface Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Postsynaptic Specialization Assembly Presynapse Assembly Insulin Metabolic Process Positive Regulation Of Protein Localization To Synapse Positive Regulation Of T-SNARE Clustering Inhibitory Synapse Assembly Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)	Mean platelet volume ( 32888494)
Interacting Genes		8 interacting genes: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ	51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN
Entrez ID		57555	1741
HPRD ID		07348	02177
Ensembl ID		ENSG00000169992	ENSG00000082458
Uniprot IDs		Q8NFZ4	Q59FY1 Q92796
PDB IDs		5XEQ 8GS4	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Vocalization Behavior Protein Localization To Cell Junction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Cell-cell Adhesion Neuron Cell-cell Adhesion Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Trans-synaptic Signaling Ionotropic Glutamate Receptor Binding Synaptic Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Establishment Or Maintenance Of Cell Polarity Learning Cell Adhesion Gephyrin Clustering Involved In Postsynaptic Density Assembly Localization Within Membrane NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Nervous System Development Postsynaptic Membrane Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cell-cell Signaling Vocal Learning Cell Junction Assembly Signaling Learning Or Memory Postsynaptic Membrane Organization Observational Learning Cell Communication Cell Projection Cell Adhesion Molecule Binding Cognition Juxtaparanode Region Of Axon Synapse Assembly Kinase Binding Postsynaptic Density Membrane Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Mechanosensory Behavior Nervous System Process	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane
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