NLGN2 and NRXN2

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)

		NLGN2	NRXN2
Gene Name		neuroligin 2	neurexin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Membrane Cell Junction Presynaptic Membrane Synapse Postsynaptic Membrane Inhibitory Synapse	Integral Component Of Membrane
	Molecular Function	Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Synapse Assembly Metabolic Process Single Organismal Cell-cell Adhesion Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering
Pathways
Drugs
Diseases
GWAS			Urate levels ( 21768215 23263486)
Protein-Protein Interactions		7 interactors: DLG2 DLG3 DLG4 INADL NRXN1 NRXN2 NRXN3	9 interactors: CASK DDX24 INADL MACF1 MAPK6 MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		57555	9379
HPRD ID		07348	11859
Ensembl ID		ENSG00000169992	ENSG00000110076
Uniprot IDs		Q8NFZ4	G5E9G7 P58401 Q9P2S2
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synaptic Transmission Synapse Assembly Neuron Cell-cell Adhesion Protein Localization To Membrane Cell-cell Signaling Postsynaptic Membrane Organization Learning Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Learning Or Memory Vocal Learning Regulation Of Grooming Behavior Cognition Postsynaptic Membrane Assembly Membrane Organization Postsynaptic Density Protein 95 Clustering Axon Guidance Neurotransmitter Secretion Auditory Behavior Single-organism Behavior Positive Regulation Of Synapse Maturation Neurological System Process Nervous System Development Regulation Of Neurotransmitter Levels Secretion By Cell Cellular Localization Axonogenesis Regulation Of Synapse Maturation Mechanosensory Behavior Axon Development Neurotransmitter Transport Adult Behavior Cellular Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Behavior Response To Auditory Stimulus Chemotaxis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Secretion Neuron Projection Morphogenesis Membrane Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Terminal Button Organization Positive Regulation Of Membrane Potential Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Synapse Assembly Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Synapse Synapse Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell Adhesion Regulation Of Ion Transport Cell-cell Junction Organization Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Regulation Of Membrane Potential Regulation Of Dendritic Spine Development Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Membrane Organization Cell-cell Signaling Protein Localization To Membrane Cellular Component Assembly Regulation Of Neuron Projection Development Positive Regulation Of Ion Transmembrane Transport
Tagcloud ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?