NLGN2 and MDGA1

Number of citations of the paper that reports this interaction (PubMedID 23248271)
44

Data Source:
BioGRID (pull down)

		NLGN2	MDGA1
Description		neuroligin 2	MAM domain containing glycosylphosphatidylinositol anchor 1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Dendritic Shaft Synapse Postsynaptic Membrane Excitatory Synapse Inhibitory Synapse Ribbon Synapse Glycinergic Synapse Dopaminergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Postsynaptic Specialization Membrane	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Axon Dendrite Side Of Membrane GABA-ergic Synapse
	Molecular Function	Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Thigmotaxis Regulation Of Respiratory Gaseous Exchange By Nervous System Process Cell Adhesion Neuron Cell-cell Adhesion Synapse Assembly Jump Response Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Cell Surface Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Postsynaptic Specialization Assembly Presynapse Assembly Insulin Metabolic Process Positive Regulation Of Protein Localization To Synapse Positive Regulation Of T-SNARE Clustering Inhibitory Synapse Assembly Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	Neuron Migration Nervous System Development Brain Development Spinal Cord Association Neuron Differentiation Cerebral Cortex Radially Oriented Cell Migration Cell Differentiation Dopamine Metabolic Process Serotonin Metabolic Process Prepulse Inhibition Presynapse Assembly Regulation Of Synaptic Membrane Adhesion Inhibitory Synapse Assembly Regulation Of Presynapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)	Acne (severe) ( 24927181) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Lamb consumption ( 32066663) Neurological blood protein biomarker levels ( 31320639) Restless legs syndrome ( 29029846)
Interacting Genes		8 interacting genes: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ	2 interacting genes: LNX2 NLGN2
Entrez ID		57555	266727
HPRD ID		07348	14374
Ensembl ID		ENSG00000169992	ENSG00000112139
Uniprot IDs		Q8NFZ4	A0A7P0TB62 Q8NFP4
PDB IDs		5XEQ 8GS4	5V5V 5V5W 5XEQ
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Vocalization Behavior Protein Localization To Cell Junction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Cell-cell Adhesion Neuron Cell-cell Adhesion Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Trans-synaptic Signaling Ionotropic Glutamate Receptor Binding Synaptic Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Establishment Or Maintenance Of Cell Polarity Learning Cell Adhesion Gephyrin Clustering Involved In Postsynaptic Density Assembly Localization Within Membrane NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Nervous System Development Postsynaptic Membrane Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cell-cell Signaling Vocal Learning Cell Junction Assembly Signaling Learning Or Memory Postsynaptic Membrane Organization Observational Learning Cell Communication Cell Projection Cell Adhesion Molecule Binding Cognition Juxtaparanode Region Of Axon Synapse Assembly Kinase Binding Postsynaptic Density Membrane Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Mechanosensory Behavior Nervous System Process	Positive Regulation Of T-SNARE Clustering Jump Response Glycinergic Synapse Ribbon Synapse Postsynaptic Membrane Assembly Terminal Button Organization Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Inhibitory Postsynaptic Potential Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Protein Localization To Synapse Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Synaptic Vesicle Clustering Thigmotaxis Neuron To Neuron Synapse Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Dopaminergic Synapse Locomotory Exploration Behavior Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Inhibitory Synapse Neurotransmitter-gated Ion Channel Clustering Presynapse Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Positive Regulation Of Synaptic Transmission, GABAergic Insulin Metabolic Process Presynapse Organization Cell-cell Junction Maintenance Regulation Of Respiratory Gaseous Exchange Inhibitory Synapse Assembly Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Regulation Of Protein Localization To Synapse Excitatory Synapse Protein Localization To Cell Surface Postsynaptic Specialization Membrane Positive Regulation Of Excitatory Postsynaptic Potential Synaptic Transmission, GABAergic Exploration Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Dendritic Spine Development Dendritic Shaft Sensory Perception Of Pain
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