NLGN2 and NRXN3

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)

		NLGN2	NRXN3
Gene Name		neuroligin 2	neurexin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Membrane Cell Junction Presynaptic Membrane Synapse Postsynaptic Membrane Inhibitory Synapse	Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Synapse Assembly Metabolic Process Single Organismal Cell-cell Adhesion Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Angiogenesis Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body mass index ( 20935630) Obesity ( 23563607 21552555) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist circumference ( 19557197)
Protein-Protein Interactions		7 interactors: DLG2 DLG3 DLG4 INADL NRXN1 NRXN2 NRXN3	5 interactors: CASK MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		57555	9369
HPRD ID		07348	08989
Ensembl ID		ENSG00000169992
Uniprot IDs		Q8NFZ4	Q9HDB5 Q9Y4C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synaptic Transmission Synapse Assembly Neuron Cell-cell Adhesion Protein Localization To Membrane Cell-cell Signaling Postsynaptic Membrane Organization Learning Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Learning Or Memory Vocal Learning Regulation Of Grooming Behavior Cognition Postsynaptic Membrane Assembly Membrane Organization Postsynaptic Density Protein 95 Clustering Axon Guidance Neurotransmitter Secretion Auditory Behavior Single-organism Behavior Positive Regulation Of Synapse Maturation Neurological System Process Nervous System Development Regulation Of Neurotransmitter Levels Secretion By Cell Cellular Localization Axonogenesis Regulation Of Synapse Maturation Mechanosensory Behavior Axon Development Neurotransmitter Transport Adult Behavior Cellular Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Behavior Response To Auditory Stimulus Chemotaxis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Secretion Neuron Projection Morphogenesis Membrane Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Terminal Button Organization Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Adhesion Synapse Assembly Regulation Of Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Postsynaptic Density Protein 95 Clustering Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Synapse Organization Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell-cell Signaling Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Synaptic Transmission Regulation Of Dendrite Development Cellular Component Assembly Cytoskeletal Matrix Organization At Active Zone
Tagcloud ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?