NLGN2 and NRXN1

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NLGN2	NRXN1
Gene Name		neuroligin 2	neurexin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Membrane Cell Junction Presynaptic Membrane Synapse Postsynaptic Membrane Inhibitory Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone
	Molecular Function	Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Synapse Assembly Metabolic Process Single Organismal Cell-cell Adhesion Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways			Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)
Protein-Protein Interactions		7 interactors: DLG2 DLG3 DLG4 INADL NRXN1 NRXN2 NRXN3	28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		57555	9378
HPRD ID		07348	11858
Ensembl ID		ENSG00000169992	ENSG00000179915
Uniprot IDs		Q8NFZ4	A4FVB9 A7E294 P58400 Q49A31 Q9ULB1
PDB IDs			3B3Q
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synaptic Transmission Synapse Assembly Neuron Cell-cell Adhesion Protein Localization To Membrane Cell-cell Signaling Postsynaptic Membrane Organization Learning Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Learning Or Memory Vocal Learning Regulation Of Grooming Behavior Cognition Postsynaptic Membrane Assembly Membrane Organization Postsynaptic Density Protein 95 Clustering Axon Guidance Neurotransmitter Secretion Auditory Behavior Single-organism Behavior Positive Regulation Of Synapse Maturation Neurological System Process Nervous System Development Regulation Of Neurotransmitter Levels Secretion By Cell Cellular Localization Axonogenesis Regulation Of Synapse Maturation Mechanosensory Behavior Axon Development Neurotransmitter Transport Adult Behavior Cellular Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Behavior Response To Auditory Stimulus Chemotaxis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Membrane Assembly Secretion Neuron Projection Morphogenesis Membrane Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity	Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization
Tagcloud ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		17p13 adipocytes array cgh disability duplication dysmorphic encodes encompassing facial fingers fissures fxr2 glut4 hyperpigmentation intellectual mandible nostrils obesity p13 palpebral proposita recognizable referred seizures slc2a4 slender tp53 upturned	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?