ZNF512B and XPC

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZNF512B	XPC
Description		zinc finger protein 512B	XPC complex subunit, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane XPC Complex Site Of DNA Damage
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Heteroduplex DNA Loop Binding Bubble DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription	Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair DNA Damage Response Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription UV-damage Excision Repair Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		RHOV GTPase cycle	SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX	17 interacting genes: BTG3 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMC5 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B
Entrez ID		57473	7508
HPRD ID		13840	02046
Ensembl ID		ENSG00000196700	ENSG00000154767
Uniprot IDs		Q96KM6	Q01831 X5DRB1
PDB IDs		2GQJ 8TX8	2A4J 2GGM 2OBH 2RVB 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing	Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Nucleoplasm Cellular Response To Stress Nucleic Acid Metabolic Process Macromolecule Metabolic Process Proteasome Complex Nucleus Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process XPC Complex Base-excision Repair Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process UV-damage Excision Repair UV Protection Transcription Factor TFIIH Core Complex Transcription-coupled Nucleotide-excision Repair Proteasome Regulatory Particle, Base Subcomplex Transcription Factor TFIIH Holo Complex DNA Replication Factor A Complex Cellular Response To UV Proteasomal Protein Catabolic Process Proteasome Accessory Complex Ubiquitin Binding Proteasome Binding Cellular Response To Light Stimulus Single-stranded DNA Binding PML Body Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Radiation Site Of DNA Damage Response To Radiation Protein-containing Complex Nucleotide-excision Repair Factor 3 Complex
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