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XPC and PSMD4
Number of citations of the paper that reports this interaction (PMID
25118285
)
0
Data Source:
BioGRID
(pull down)
XPC
PSMD4
Gene Name
xeroderma pigmentosum, complementation group C
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Plasma Membrane
Extracellular Vesicular Exosome
XPC Complex
Proteasome Complex
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
Heteroduplex DNA Loop Binding
Bubble DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Protein Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Nucleotide-excision Repair
Response To UV-B
Intra-S DNA Damage Checkpoint
Response To Drug
Regulation Of Mitotic Cell Cycle Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Nucleotide Excision Repair
Global Genomic NER (GG-NER)
Formation of incision complex in GG-NER
DNA Damage Recognition in GG-NER
Dual incision reaction in GG-NER
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
ABCA1
CETN2
DDB2
ERCC3
GTF2H1
LSM3
MDM2
PSMD4
RAD23A
RAD23B
RPA1
SMAD1
SUMO2
TDG
USP7
ZNF512B
41 interactors:
ADRM1
APP
BTRC
CCNA2
CCNB1
COPS2
COPS7A
CUL1
EGFR
ELSPBP1
FBXO25
FLOT1
GNB5
ID1
MDM2
MYOD1
NEDD4
NEDD4L
NEDD8
NUB1
NUPR1
PARK2
PSMC2
RAD23A
RAD23B
RASSF8
RBCK1
SCHIP1
SIAH2
SREBF2
STUB1
TCF3
TRIM63
UBB
UBC
UBE2C
UBE3A
UBQLN1
UBQLN2
UBQLN4
XPC
Entrez ID
7508
5710
HPRD ID
02046
03386
Ensembl ID
ENSG00000154767
ENSG00000159352
Uniprot IDs
Q01831
P55036
Q5VWC4
PDB IDs
2A4J
2GGM
2OBH
1P9C
1P9D
1UEL
1YX4
1YX5
1YX6
2KDE
2KDF
Enriched GO Terms of Interacting Partners
?
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
Cellular Macromolecule Catabolic Process
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Cellular Response To Stress
DNA Catabolic Process
Catabolic Process
Response To Stress
DNA Metabolic Process
Aromatic Compound Catabolic Process
Transcription-coupled Nucleotide-excision Repair
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Viral Process
Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Proteolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression, Epigenetic
Cellular Protein Metabolic Process
Cellular Response To Stimulus
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Viral Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Catabolic Process
Chromosome Organization
Protein Catabolic Process
Cellular Protein Modification Process
Response To UV
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Protein Metabolic Process
Termination Of RNA Polymerase I Transcription
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Viral Process
Transcription Elongation From RNA Polymerase I Promoter
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Transcription Initiation From RNA Polymerase I Promoter
Metabolic Process
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase I Promoter
Regulation Of Cell Cycle Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Regulation Of Protein Catabolic Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteolysis
Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Protein Metabolic Process
Protein Polyubiquitination
Regulation Of Cellular Protein Metabolic Process
Proteolysis
Cellular Protein Modification Process
Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Proteasomal Protein Catabolic Process
Cellular Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Protein Metabolic Process
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cell Cycle
Cellular Response To Stress
Viral Process
Positive Regulation Of Metabolic Process
Tagcloud
?
confirm
degradation
demonstrating
dominant
e3
exploited
extend
incorporated
interacting
interferring
ligase
mdm2
modulate
motifs
p53
participates
proteasomal
proteasome
recognition
rescue
rpn10
s5a
selectively
selectivity
stabilization
ubiquitin
ubiquitinated
uim
uims
Tagcloud (Difference)
?
confirm
degradation
demonstrating
dominant
e3
exploited
extend
incorporated
interacting
interferring
ligase
mdm2
modulate
motifs
p53
participates
proteasomal
proteasome
recognition
rescue
rpn10
s5a
selectively
selectivity
stabilization
ubiquitin
ubiquitinated
uim
uims
Tagcloud (Intersection)
?