XPC and USP7

Number of citations of the paper that reports this interaction (PMID 25118285)
0

Data Source:
BioGRID (enzymatic study)

		XPC	USP7
Gene Name		xeroderma pigmentosum, complementation group C	ubiquitin specific peptidase 7 (herpes virus-associated)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Extracellular Vesicular Exosome XPC Complex	Nucleus Cytosol PML Body
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To UV-B Intra-S DNA Damage Checkpoint Response To Drug Regulation Of Mitotic Cell Cycle Phase Transition	Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ABCA1 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 SUMO2 TDG USP7 ZNF512B	85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423
Entrez ID		7508	7874
HPRD ID		02046	03950
Ensembl ID		ENSG00000154767	ENSG00000187555
Uniprot IDs		Q01831	B7Z815 Q6U8A4 Q93009
PDB IDs		2A4J 2GGM 2OBH	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Repair Cellular Response To Stress DNA Catabolic Process Catabolic Process Response To Stress DNA Metabolic Process Aromatic Compound Catabolic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Viral Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Protein Metabolic Process Cellular Response To Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Chromosome Organization Protein Catabolic Process Cellular Protein Modification Process Response To UV Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Metabolic Process Termination Of RNA Polymerase I Transcription Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of Cellular Protein Metabolic Process Response To Stimulus Transcription Initiation From RNA Polymerase I Promoter Metabolic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Regulation Of Cell Cycle Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death
Tagcloud ?			accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Difference) ?			accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Intersection) ?