XPC and RPA1

Number of citations of the paper that reports this interaction (PubMedID 37827155)
181

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, pull down)

		XPC	RPA1
Description		XPC complex subunit, DNA damage recognition and repair factor	replication protein A1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane XPC Complex Site Of DNA Damage	Nuclear Chromosome Chromosome, Telomeric Region Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Damage Sensor Activity	Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding Chromatin-protein Adaptor Activity
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair DNA Damage Response Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription UV-damage Excision Repair Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination Chromatin Organization DNA Damage Response Telomere Maintenance Via Telomerase Positive Regulation Of Cell Population Proliferation Hemopoiesis Protein Localization To Chromosome Homeostasis Of Number Of Cells Within A Tissue Chromosome Organization Meiotic Cell Cycle Protein Localization To Site Of Double-strand Break
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172)	Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: BTG3 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMC5 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	70 interacting genes: AICDA AJUBA AKTIP ASCC2 ATM ATR BLM BRCA2 BRIP1 CCNA1 CEBPA CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 GNB5 GRB2 HAX1 HELB HGH1 HIRA HNRNPUL1 HSPA6 HUS1 KAT2A KAT2B MCM2 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RECQL RFWD3 RIPK1 RNF20 RNF40 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WAS WRN XPA XPC ZBTB14
Entrez ID		7508	6117
HPRD ID		02046	01565
Ensembl ID		ENSG00000154767	ENSG00000132383
Uniprot IDs		Q01831 X5DRB1	P27694
PDB IDs		2A4J 2GGM 2OBH 2RVB 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY	1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A 7XUT 7XUV 7XUW 7XV0 7XV1 7XV4 8JZV 8JZY 8K00 8RK2 9J1S 9MJ5
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Nucleoplasm Cellular Response To Stress Nucleic Acid Metabolic Process Macromolecule Metabolic Process Proteasome Complex Nucleus Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process XPC Complex Base-excision Repair Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process UV-damage Excision Repair UV Protection Transcription Factor TFIIH Core Complex Transcription-coupled Nucleotide-excision Repair Proteasome Regulatory Particle, Base Subcomplex Transcription Factor TFIIH Holo Complex DNA Replication Factor A Complex Cellular Response To UV Proteasomal Protein Catabolic Process Proteasome Accessory Complex Ubiquitin Binding Proteasome Binding Cellular Response To Light Stimulus Single-stranded DNA Binding PML Body Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Radiation Site Of DNA Damage Response To Radiation Protein-containing Complex Nucleotide-excision Repair Factor 3 Complex	DNA Metabolic Process DNA Repair DNA Damage Response DNA Recombination Cellular Response To Stress Double-strand Break Repair Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Single-stranded DNA Binding Cellular Response To Radiation Nucleoplasm DNA Replication Nucleotide-excision Repair DNA Damage Checkpoint Signaling Response To Ionizing Radiation Response To Radiation Site Of Double-strand Break Replication Fork Processing Chromosome, Telomeric Region Chromosome Organization Cellular Response To Ionizing Radiation Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Telomere Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Mismatch Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Response To UV Regulation Of Cellular Response To Stress DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding DNA Replication Factor A Complex MutLalpha Complex Binding Response To Gamma Radiation Mitotic Recombination DNA Helicase Activity
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