ZNF512B and TNKS2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZNF512B	TNKS2
Description		zinc finger protein 512B	tankyrase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Envelope Chromosome Cytoplasm Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription	Protein Polyubiquitination Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		RHOV GTPase cycle	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)	Appendicular lean mass ( 33097823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver volume ( 34128465) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX	17 interacting genes: AMOTL2 ANKRD28 ARAP3 DSCR9 GRB14 LNPEP MAPK1 MAVS MDC1 PTEN SASH1 SH3BP2 TERF1 TNKS TNKS1BP1 USP25 ZNF512B
Entrez ID		57473	80351
HPRD ID		13840	06182
Ensembl ID		ENSG00000196700	ENSG00000107854
Uniprot IDs		Q96KM6	Q9H2K2
PDB IDs		2GQJ 8TX8	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT 5OWS 5OWT 6TG4 6TKM 6TKN 6TKP 6TKQ 6TKR 6TKS 7A1S 7O6X 7POX 7R3Z 8ALY
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing	Protein Polyubiquitination Ankyrin Repeat Binding Positive Regulation Of Telomere Maintenance Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process Telomere Maintenance Via Telomerase Protein Ubiquitination RNA-templated DNA Biosynthetic Process Negative Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Modification By Small Protein Conjugation Molecular Adaptor Activity Protein Modification Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To DsRNA Phosphotyrosine Residue Binding Response To Exogenous DsRNA Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of IP-10 Production Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cytosine Metabolic Process Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Regulation Of Epithelial Cell Migration Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Regulation Of Peroxisome Organization Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Interleukin-34-mediated Signaling Pathway Regulation Of Cell-substrate Junction Organization
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