ZNF512B and PAPPA2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZNF512B	PAPPA2
Description		zinc finger protein 512B	pappalysin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription	Regulation Of Cell Growth Proteolysis Cell Surface Receptor Signaling Pathway Response To Salt Stress Bone Morphogenesis
Pathways		RHOV GTPase cycle	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 25429064 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Offspring birth weight ( 31043758) Pediatric central nervous system tumors (late onset)(pleiotropy) ( 33226468) Pediatric central nervous system tumors (pleiotropy) ( 33226468) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 30578418 27841878) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX	5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B
Entrez ID		57473	60676
HPRD ID		13840	10156
Ensembl ID		ENSG00000196700	ENSG00000116183
Uniprot IDs		Q96KM6	Q9BXP8
PDB IDs		2GQJ 8TX8	8SL1
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing	Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Muscle Hypertrophy Growth Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Regulation Of MiRNA Transcription Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of MiRNA Metabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of Growth Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Cell Population Proliferation Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epithelial Cell Proliferation Protein Tyrosine Phosphatase Activator Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Macromolecule Biosynthetic Process Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Negative Regulation Of Biosynthetic Process Sulfate Binding Endocardial Cell Differentiation Regulation Of Primary Metabolic Process MAPK Cascade Negative Regulation Of Growth Regulation Of Muscle System Process Transcription Regulator Complex SMAD Protein Complex
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