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ZNF512B and DVL3
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
BioGRID
(two hybrid)
ZNF512B
DVL3
Gene Name
zinc finger protein 512B
dishevelled segment polarity protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Molecular Function
DNA Binding
Metal Ion Binding
Protease Binding
Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Protein Heterodimerization Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Positive Regulation Of Protein Phosphorylation
Outflow Tract Septum Morphogenesis
Wnt Signaling Pathway
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT mediated activation of DVL
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by Wnt
Signaling by WNT in cancer
PCP/CE pathway
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Major depressive disorder (
22472876
)
Protein-Protein Interactions
60 interactors:
ANKLE2
ANKRD28
AP1G1
APLP2
ATRX
BRD1
BTBD2
CDC123
CREBZF
CTBP2
DCTN1
DDX3X
DROSHA
DVL3
EHMT2
FAM129B
FHL3
GLRX3
HEYL
HTATSF1
IL36RN
INVS
KDM2A
KDM3B
KLF10
KMT2B
L1TD1
LAMB2
LZTS2
MBD1
MYH10
OS9
PAPPA2
PBRM1
PDE4DIP
PEG10
PIAS4
PLCG2
PPP1R15A
PTPRF
RPS27A
SDF4
SIAH1
SMAD1
SPTBN1
SUPT5H
TGM2
TNKS2
TOM1
TOX4
TRAF1
TRAF4
VHL
VPS35
VPS41
VWF
XPC
XRCC6
YES1
ZMYM2
48 interactors:
ADAP1
AXIN1
BAHD1
C8orf33
CCNK
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
DAB2
DIDO1
DPPA2
DVL1
ENKD1
FAM13C
KAT7
KLF3
KLHL12
LNX1
LRRK2
LY6H
MARK2
MATN2
NKD1
NOL12
NXF1
PIK3CB
PITX1
PLN
PPM1A
PPP2CA
PRPF3
PSMF1
RPS10
RWDD2B
SNX22
STOM
SYT6
TNFAIP8L1
UTP3
VANGL1
WT1
YTHDC1
ZBTB48
ZNF264
ZNF408
ZNF512B
ZNF697
Entrez ID
57473
1857
HPRD ID
13840
03222
Ensembl ID
ENSG00000196700
ENSG00000161202
Uniprot IDs
Q96KM6
Q92997
PDB IDs
2GQJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Cellular Process
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organ Development
System Development
Transcription, DNA-templated
Developmental Process
Chromosome Organization
Anatomical Structure Development
Regulation Of Gene Expression
RNA Biosynthetic Process
Response To Stimulus
Negative Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression, Epigenetic
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Cell Cycle
Cellular Response To Stimulus
Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cell Cycle Process
Multicellular Organismal Development
Viral Genome Replication
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Organization
Wnt Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Cell Surface Receptor Signaling Pathway
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Chromatin Remodeling
RNA Metabolic Process
Primary MiRNA Processing
Vesicle-mediated Transport
Endosomal Transport
Regulation Of Signal Transduction
Cellular Response To Stress
Mitotic Cell Cycle Process
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Gene Expression
Response To Stress
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Wnt Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Gene Expression
RNA Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Transcription, DNA-templated
Nitrogen Compound Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cell Morphogenesis
Regulation Of Proteolysis
Regulation Of Cellular Component Organization
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Protein Modification Process
Macromolecule Biosynthetic Process
Negative Regulation Of Binding
Regulation Of Gene Expression
Cellular Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transferase Activity
Regulation Of Transcription, DNA-templated
Regulation Of Kinase Activity
Protein Complex Assembly
Tagcloud
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Difference)
?
achieves
adaptor
analogous
blockade
dab2
encouraging
erks
grb2
igfi
igfir
influencing
insufficient
links
mek
nonredundant
pharmacologic
postreceptor
relied
responded
sensitization
sensitizing
sevenless
shc
son
sos
synergized
tracked
unselected
Tagcloud (Intersection)
?