ZNF512B and KDM2A

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZNF512B	KDM2A
Description		zinc finger protein 512B	lysine demethylase 2A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription	Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process
Pathways		RHOV GTPase cycle	HDMs demethylate histones
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 28270201 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX	11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B
Entrez ID		57473	22992
HPRD ID		13840	05741
Ensembl ID		ENSG00000196700	ENSG00000173120
Uniprot IDs		Q96KM6	I3VM53 I3VM54 Q9Y2K7
PDB IDs		2GQJ 8TX8	2YU1 2YU2 4BBQ 6BYH 6C16 7UV9
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing	Transcription Regulator Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding SMAD Protein Signal Transduction Negative Regulation Of MiRNA Transcription Transcription Coactivator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Cellular Response To Growth Factor Stimulus Chromatin Response To Hormone Beta-catenin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Response To Growth Factor I-SMAD Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Chondrocyte Differentiation Double-stranded DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Intracellular Protein Transport Response To Angiotensin Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muscle Stretch Cellular Response To Cytokine Stimulus R-SMAD Binding Regulation Of T-helper 17 Cell Differentiation Intracellular Signaling Cassette Positive Regulation Of Cell Development Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation NF-kappaB Binding Positive Regulation Of Cartilage Development DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Response To Progesterone Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process
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