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ZNF512B and PLCG2
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
BioGRID
(two hybrid)
ZNF512B
PLCG2
Gene Name
zinc finger protein 512B
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Metal Ion Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Signal Transducer Activity
Protein Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Follicular B Cell Differentiation
Phosphatidylinositol Biosynthetic Process
Blood Coagulation
Phospholipid Catabolic Process
Regulation Of Gene Expression
Wnt Signaling Pathway
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Activation Of Store-operated Calcium Channel Activity
Response To Lipopolysaccharide
Inositol Trisphosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Programmed Cell Death
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Pathways
Signaling by the B Cell Receptor (BCR)
DAP12 interactions
FCERI mediated MAPK activation
Inositol phosphate metabolism
DAP12 signaling
Toll-Like Receptors Cascades
Synthesis of IP3 and IP4 in the cytosol
Toll Like Receptor 4 (TLR4) Cascade
Role of phospholipids in phagocytosis
GPVI-mediated activation cascade
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Fcgamma receptor (FCGR) dependent phagocytosis
Platelet activation, signaling and aggregation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
60 interactors:
ANKLE2
ANKRD28
AP1G1
APLP2
ATRX
BRD1
BTBD2
CDC123
CREBZF
CTBP2
DCTN1
DDX3X
DROSHA
DVL3
EHMT2
FAM129B
FHL3
GLRX3
HEYL
HTATSF1
IL36RN
INVS
KDM2A
KDM3B
KLF10
KMT2B
L1TD1
LAMB2
LZTS2
MBD1
MYH10
OS9
PAPPA2
PBRM1
PDE4DIP
PEG10
PIAS4
PLCG2
PPP1R15A
PTPRF
RPS27A
SDF4
SIAH1
SMAD1
SPTBN1
SUPT5H
TGM2
TNKS2
TOM1
TOX4
TRAF1
TRAF4
VHL
VPS35
VPS41
VWF
XPC
XRCC6
YES1
ZMYM2
34 interactors:
BLK
BLNK
BTK
CBLB
CD19
DAPP1
EGFR
EPOR
ERBB2
FCER1G
FLT1
FYN
GAB1
GAB2
HCK
IRS1
ITK
JAK1
JAK2
KDR
KHDRBS1
LAT
LAT2
LCK
LCP2
LIME1
LYN
NPM1
PRKD1
SH3BP2
SHC1
SYK
TEC
ZNF512B
Entrez ID
57473
5336
HPRD ID
13840
02570
Ensembl ID
ENSG00000196700
ENSG00000197943
Uniprot IDs
Q96KM6
P16885
PDB IDs
2GQJ
2K2J
2W2W
2W2X
Enriched GO Terms of Interacting Partners
?
Regulation Of Cellular Process
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organ Development
System Development
Transcription, DNA-templated
Developmental Process
Chromosome Organization
Anatomical Structure Development
Regulation Of Gene Expression
RNA Biosynthetic Process
Response To Stimulus
Negative Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression, Epigenetic
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Cell Cycle
Cellular Response To Stimulus
Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cell Cycle Process
Multicellular Organismal Development
Viral Genome Replication
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Organization
Wnt Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Cell Surface Receptor Signaling Pathway
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Chromatin Remodeling
RNA Metabolic Process
Primary MiRNA Processing
Vesicle-mediated Transport
Endosomal Transport
Regulation Of Signal Transduction
Cellular Response To Stress
Mitotic Cell Cycle Process
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Gene Expression
Response To Stress
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Innate Immune Response
Peptidyl-tyrosine Autophosphorylation
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response
Protein Autophosphorylation
Immune System Process
Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Defense Response
Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signaling
Cell Communication
B Cell Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stimulus
Regulation Of Cell Proliferation
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Peptidyl-amino Acid Modification
Cell Activation
Positive Regulation Of Signal Transduction
Response To Stimulus
Response To Stress
Leukocyte Activation
Protein Phosphorylation
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of Cell Activation
Cell Migration
Locomotion
Phosphorylation
Cell Motility
Mast Cell Activation
Phosphatidylinositol-mediated Signaling
Wound Healing
Leukocyte Migration
Movement Of Cell Or Subcellular Component
Regulation Of Signaling
Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Tagcloud
?
16x10
associations
chrne
comprehensively
dysregulated
escc
esccs
esophageal
fyn
gc
gcs
germline
gnai3
han
itch
map2k1
map2k4
mapk8
observe
pak4
pik3r3
prlr
rank
resampling
rps6kb2
tln1
validate
warranted
wasl
Tagcloud (Difference)
?
16x10
associations
chrne
comprehensively
dysregulated
escc
esccs
esophageal
fyn
gc
gcs
germline
gnai3
han
itch
map2k1
map2k4
mapk8
observe
pak4
pik3r3
prlr
rank
resampling
rps6kb2
tln1
validate
warranted
wasl
Tagcloud (Intersection)
?