XPC and GTF2H1

Number of citations of the paper that reports this interaction (PMID 11259578)
49

Data Source:
HPRD (in vivo)

		XPC	GTF2H1
Gene Name		xeroderma pigmentosum, complementation group C	general transcription factor IIH, polypeptide 1, 62kDa
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Extracellular Vesicular Exosome XPC Complex	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To UV-B Intra-S DNA Damage Checkpoint Response To Drug Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)
Protein-Protein Interactions		16 interactors: ABCA1 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 SUMO2 TDG USP7 ZNF512B	42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1
Entrez ID		7508	2965
HPRD ID		02046	01807
Ensembl ID		ENSG00000154767	ENSG00000110768
Uniprot IDs		Q01831	P32780
PDB IDs		2A4J 2GGM 2OBH	1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Repair Cellular Response To Stress DNA Catabolic Process Catabolic Process Response To Stress DNA Metabolic Process Aromatic Compound Catabolic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Viral Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Protein Metabolic Process Cellular Response To Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Chromosome Organization Protein Catabolic Process Cellular Protein Modification Process Response To UV Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Metabolic Process Termination Of RNA Polymerase I Transcription Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of Cellular Protein Metabolic Process Response To Stimulus Transcription Initiation From RNA Polymerase I Promoter Metabolic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Regulation Of Cell Cycle Process	Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress
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