ZNF512B and DROSHA

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ZNF512B	DROSHA
Description		zinc finger protein 512B	drosha ribonuclease III
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Organelle Microprocessor Complex Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Lipopolysaccharide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Protein Binding Hydrolase Activity DEAD/H-box RNA Helicase Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding R-SMAD Binding Primary MiRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription	RRNA Processing RNA Processing Regulation Of Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Pre-miRNA Processing MiRNA Processing Ribosome Biogenesis Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of MiRNA Metabolic Process
Pathways		RHOV GTPase cycle	MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)	Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Height ( 33713608) Lung function (FEV1) ( 26635082) Tuberculosis ( 30713548)
Interacting Genes		72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX	6 interacting genes: DGCR8 DYRK1A RNF10 SP1 TULP3 ZNF512B
Entrez ID		57473	29102
HPRD ID		13840	10196
Ensembl ID		ENSG00000196700	ENSG00000113360
Uniprot IDs		Q96KM6	Q9NRR4
PDB IDs		2GQJ 8TX8	2KHX 2NA2 5B16 6LXD 6LXE 6V5B 6V5C 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing	Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Regulation Of Gene Expression Histone H3T45 Kinase Activity Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Intraciliary Transport Particle A Binding Regulation Of RNA Metabolic Process Negative Regulation Of Heterochromatin Formation Regulation Of Metabolic Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Protein-RNA Adaptor Activity Positive Regulation Of MiRNA Processing Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Cellular Response To Zinc Ion Starvation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Heterochromatin Formation Neural Tube Formation Embryonic Neurocranium Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Primary MiRNA Binding Rhythmic Process Transcription Cis-regulatory Region Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity 9+0 Non-motile Cilium Neurofilament Dorsal/ventral Neural Tube Patterning Positive Regulation Of MiRNA-mediated Gene Silencing Primary MiRNA Processing Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Development Regulation Of MiRNA Processing
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