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EXOSC5 and DOCK8
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
EXOSC5
DOCK8
Gene Name
exosome component 5
dedicator of cytokinesis 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Cytosol
Membrane
Cell Leading Edge
Molecular Function
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Immunological Synapse Formation
Small GTPase Mediated Signal Transduction
Blood Coagulation
Dendritic Cell Migration
Positive Regulation Of GTPase Activity
Memory T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
32 interactors:
BIRC2
CALCOCO2
CDK5RAP1
DHRS2
DIS3
DOCK8
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
GOLGA2
IKZF3
KIAA1217
KRT13
LIPG
LSM5
MPP6
NUP210
PA2G4
PKM
POLR2L
REL
SFPQ
SKIV2L2
TNFAIP1
TRIM54
ZNF558
25 interactors:
BYSL
CARHSP1
CDC42
CHMP2A
DGCR6
EXOSC5
FAM124A
FAM161A
FANCL
FBXL12
HBZ
KRT40
LRCH1
LRCH3
MED30
MEOX2
MRPL38
MTG1
RAC1
RHOJ
RHOQ
RTP5
SMAD2
ZFC3H1
ZNF581
Entrez ID
56915
81704
HPRD ID
16222
10920
Ensembl ID
ENSG00000077348
ENSG00000107099
Uniprot IDs
M0R050
Q9NQT4
E2J6M5
E2J6M6
Q8NF50
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
NcRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RNA Metabolic Process
Maturation Of 5.8S RRNA
Nuclear MRNA Surveillance
Aromatic Compound Catabolic Process
RNA Surveillance
Cellular Macromolecule Catabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
Nucleic Acid Phosphodiester Bond Hydrolysis
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
RNA Processing
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
Cellular Metabolic Process
RNA Localization
DNA Deamination
Immune System Process
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Immune Response
Leukocyte Activation
Isotype Switching
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Anatomical Structure Morphogenesis
Posttranscriptional Regulation Of Gene Expression
Ribosome Biogenesis
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Filopodium Assembly
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Centriole Elongation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lipid Kinase Activity
Anatomical Structure Formation Involved In Morphogenesis
Actin Cytoskeleton Organization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Replication
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Projection Organization
Cell Projection Assembly
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Hair Follicle Cell Proliferation
Actin Filament-based Process
T Cell Costimulation
Positive Regulation Of Cellular Component Biogenesis
Ribonucleoprotein Complex Biogenesis
Embryonic Pattern Specification
Regulation Of Protein Complex Assembly
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Engulfment Of Apoptotic Cell
Submandibular Salivary Gland Formation
Actin Filament Branching
Zygotic Specification Of Dorsal/ventral Axis
Regulation Of Small GTPase Mediated Signal Transduction
Anatomical Structure Development
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mast Cell Chemotaxis
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Palate Development
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Mitotic Nuclear Division
Tagcloud
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Difference)
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Intersection)
?