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EXOSC5 and FCHO1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
EXOSC5
FCHO1
Gene Name
exosome component 5
FCH domain only 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Plasma Membrane
Coated Pit
Clathrin-coated Vesicle
Molecular Function
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Protein Binding
AP-2 Adaptor Complex Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Clathrin Coat Assembly
Clathrin-mediated Endocytosis
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
32 interactors:
BIRC2
CALCOCO2
CDK5RAP1
DHRS2
DIS3
DOCK8
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
GOLGA2
IKZF3
KIAA1217
KRT13
LIPG
LSM5
MPP6
NUP210
PA2G4
PKM
POLR2L
REL
SFPQ
SKIV2L2
TNFAIP1
TRIM54
ZNF558
7 interactors:
ACVR1
APP
EXOSC5
LGALS14
PTK6
SMURF1
ZBTB16
Entrez ID
56915
23149
HPRD ID
16222
16887
Ensembl ID
ENSG00000077348
ENSG00000130475
Uniprot IDs
M0R050
Q9NQT4
B7ZAZ3
O14526
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
NcRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RNA Metabolic Process
Maturation Of 5.8S RRNA
Nuclear MRNA Surveillance
Aromatic Compound Catabolic Process
RNA Surveillance
Cellular Macromolecule Catabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
Nucleic Acid Phosphodiester Bond Hydrolysis
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
RNA Processing
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
Cellular Metabolic Process
RNA Localization
DNA Deamination
Immune System Process
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Immune Response
Leukocyte Activation
Isotype Switching
Regulation Of Ossification
Regulation Of Protein Tyrosine Kinase Activity
BMP Signaling Pathway
Endocardial Cushion Cell Fate Commitment
Defense Response
Positive Regulation Of Ossification
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cell Differentiation
Synaptic Growth At Neuromuscular Junction
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Protein Modification Process
Tissue Development
Collateral Sprouting In Absence Of Injury
Cell Differentiation
Regulation Of Transcription From RNA Polymerase II Promoter
Tyrosine Phosphorylation Of Stat5 Protein
Sexual Reproduction
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Collateral Sprouting
Axon Midline Choice Point Recognition
Positive Regulation Of NK T Cell Differentiation
Positive Regulation Of Cell Differentiation
Regulation Of Peptidyl-tyrosine Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Mitral Valve Morphogenesis
Tyrosine Phosphorylation Of Stat3 Protein
Male Germ-line Stem Cell Asymmetric Division
Cardiac Muscle Cell Fate Commitment
Immune System Process
Mitral Valve Development
Axon Choice Point Recognition
Ubiquitin-dependent SMAD Protein Catabolic Process
Apoptotic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Germ Cell Development
Programmed Cell Death
Positive Regulation Of Determination Of Dorsal Identity
DNA Deamination
Reproduction
Cell Death
Death
Neuron Remodeling
Negative Regulation Of Activin Receptor Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein Phosphorylation
Atrial Septum Primum Morphogenesis
Endocardial Cell Differentiation
Cellular Protein Metabolic Process
Tagcloud
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abp1
ack1
amphiphysin1
arp3
calm
ccs
ccss
cip4
cme
coronin1b
decoding
dynamin1
endophilin2
engulfed
eps15
eps8
epsin2
fbp17
gak
hip1r
lifeact
myosin1e
myosin6
necap
ocrl1
scission
snx9
synaptojanin2beta1
syndapin2
Tagcloud (Difference)
?
abp1
ack1
amphiphysin1
arp3
calm
ccs
ccss
cip4
cme
coronin1b
decoding
dynamin1
endophilin2
engulfed
eps15
eps8
epsin2
fbp17
gak
hip1r
lifeact
myosin1e
myosin6
necap
ocrl1
scission
snx9
synaptojanin2beta1
syndapin2
Tagcloud (Intersection)
?