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EXOSC5 and PA2G4
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
EXOSC5
PA2G4
Gene Name
exosome component 5
proliferation-associated 2G4, 38kDa
Image
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Membrane
Ribonucleoprotein Complex
Extracellular Vesicular Exosome
Molecular Function
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Transcription, DNA-templated
RRNA Processing
Regulation Of Translation
Cell Cycle Arrest
Cell Proliferation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Vitiligo (
22951725
)
Protein-Protein Interactions
32 interactors:
BIRC2
CALCOCO2
CDK5RAP1
DHRS2
DIS3
DOCK8
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
GOLGA2
IKZF3
KIAA1217
KRT13
LIPG
LSM5
MPP6
NUP210
PA2G4
PKM
POLR2L
REL
SFPQ
SKIV2L2
TNFAIP1
TRIM54
ZNF558
20 interactors:
AR
ATR
ERBB3
EXOSC5
FUS
HDAC2
HMGA1
HMGA2
IKBKG
LIG4
MTOR
PRKCA
PRKCB
PRKCG
RB1
RNF20
SIN3A
SUMO4
TERF1
UBC
Entrez ID
56915
5036
HPRD ID
16222
03685
Ensembl ID
ENSG00000077348
ENSG00000170515
Uniprot IDs
M0R050
Q9NQT4
Q9UQ80
PDB IDs
2NN6
2Q8K
3J2I
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
RRNA Processing
RRNA Metabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
NcRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
Ribonucleoprotein Complex Biogenesis
MRNA Catabolic Process
RNA Catabolic Process
MRNA Metabolic Process
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RNA Metabolic Process
Maturation Of 5.8S RRNA
Nuclear MRNA Surveillance
Aromatic Compound Catabolic Process
RNA Surveillance
Cellular Macromolecule Catabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
Nucleic Acid Phosphodiester Bond Hydrolysis
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
RNA Processing
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
Cellular Metabolic Process
RNA Localization
DNA Deamination
Immune System Process
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Immune Response
Leukocyte Activation
Isotype Switching
Chromatin Modification
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Chromatin Organization
Chromosome Organization
Regulation Of Apoptotic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Neurotrophin Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Cellular Metabolic Process
DNA Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Signaling
Negative Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune System Process
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cell Aging
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Histone Modification
Histone H3-T6 Phosphorylation
Oncogene-induced Cell Senescence
Regulation Of Mitotic Cell Cycle
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Cycle Process
Cell Cycle Checkpoint
Regulation Of Cell Proliferation
Nitrogen Compound Metabolic Process
Cellular Response To Stress
Tagcloud
?
a8
acidic
acting
afgf
agnwtpi
ap8
arrested
biopanning
clone
competed
contained
display
erk1
fgfr1
fgfrs
fibroblast
g0
gtpnptl
heptapeptide
homology
identical
library
named
pcna
peptide
phage
rounds
suppressing
tp
Tagcloud (Difference)
?
a8
acidic
acting
afgf
agnwtpi
ap8
arrested
biopanning
clone
competed
contained
display
erk1
fgfr1
fgfrs
fibroblast
g0
gtpnptl
heptapeptide
homology
identical
library
named
pcna
peptide
phage
rounds
suppressing
tp
Tagcloud (Intersection)
?