EXOSC5 and CDK5RAP1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		EXOSC5	CDK5RAP1
Gene Name		exosome component 5	CDK5 regulatory subunit associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Cellular_component Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Transferase Activity Protein Kinase Binding Protein Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	TRNA Modification Brain Development Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558	4 interactors: CDK5 CDK5R1 EXOSC3 EXOSC5
Entrez ID		56915	51654
HPRD ID		16222	12189
Ensembl ID		ENSG00000077348	ENSG00000101391
Uniprot IDs		M0R050 Q9NQT4	Q53H36 Q96SZ6
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching	Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein DNA Deamination Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Axon Extension Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Protein Targeting To Membrane Regulation Of Dendritic Spine Morphogenesis Layer Formation In Cerebral Cortex Cerebral Cortex Radial Glia Guided Migration Peptidyl-threonine Phosphorylation Regulation Of Dendritic Spine Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Hippocampus Development Positive Regulation Of Neuron Death DNA Modification Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Limbic System Development Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development RNA Phosphodiester Bond Hydrolysis Cerebellum Development Peptidyl-serine Phosphorylation Negative Regulation Of Neuron Projection Development Metencephalon Development RRNA Processing Regulation Of Cell Size RRNA Metabolic Process Negative Regulation Of Cell Projection Organization Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Cell Growth Regulation Of Axonogenesis MRNA Catabolic Process Cerebral Cortex Development Positive Regulation Of Intracellular Protein Transport Neuron Migration Hindbrain Development Superior Olivary Nucleus Maturation
Tagcloud ?			acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world
Tagcloud (Difference) ?			acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world
Tagcloud (Intersection) ?