EXOSC5 and CCDC88B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EXOSC5	CCDC88B
Description		exosome component 5	coiled-coil and HOOK domain protein 88B
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding	Protein Binding Microtubule Binding Dynein Light Intermediate Chain Binding
	Biological Process	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing	Positive Regulation Of Cytokine Production Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Positive Regulation Of T Cell Proliferation Defense Response To Protozoan Positive Regulation Of T Cell Activation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Basal cell carcinoma ( 31174203 33549134) Crohn's disease ( 28067908) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 23128233) Keratinocyte cancer (MTAG) ( 31174203) Leprosy ( 25642632) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 26394269) Primary sclerosing cholangitis ( 27992413) Sarcoidosis ( 22837380) Triglyceride levels ( 32154731) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		82 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	41 interacting genes: AIRIM BEX2 CARD9 CCHCR1 CDK18 CWF19L2 DEF6 DTNB EXOSC5 FAM161A FAM161B GEM HCK HOXB5 JAKMIP2 KANK2 LMNB1 LMNB2 LMO1 LNX1 NME7 PBX2 PIN1 PLEKHA5 PPP1R18 RALBP1 RBM7 RINT1 SH2D4A SH3KBP1 SRPK2 TBC1D22B TRAF3IP3 TSC1 TSG101 TSGA10 TSGA10IP TSHZ2 TXLNB USP2 ZC2HC1C
Entrez ID		56915	283234
HPRD ID		16222	10986
Ensembl ID		ENSG00000077348	ENSG00000168071
Uniprot IDs		Q9NQT4	A6NC98 B2RTU8
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination	Protein Binding Nuclear Pore Localization 14-3-3 Protein Binding
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