EXOSC5 and KRT13

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EXOSC5	KRT13
Gene Name		exosome component 5	keratin 13, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nucleus Keratin Filament Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Structural Molecule Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Cytoskeleton Organization Response To Radiation Tongue Morphogenesis Cellular Response To Retinoic Acid
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558	46 interactors: ABI2 ABI3 AES ALS2CR11 AMOTL2 ANKRD36BP1 APC ATP5O BLOC1S6 C1orf109 C1orf216 CCDC101 CCHCR1 CCNC CEP57 CEP57L1 EIF4E2 EXOSC5 FAM127C FARS2 FBF1 GFAP GOLGA8EP IFT20 KLC3 KLC4 KRT2 KRT20 KRT4 KRT6A KRT6B KRT6C KRT7 KRT71 KRT79 KRT8 LSM2 MOS MYH1 PPP1R18 PSMB1 PSMB2 TMSB4X TRIM42 TSG101 TXLNA
Entrez ID		56915	3860
HPRD ID		16222	01016
Ensembl ID		ENSG00000077348	ENSG00000171401
Uniprot IDs		M0R050 Q9NQT4	A1A4E9 P13646
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching	Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Microtubule-based Process Cellular Localization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Skin Development Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Establishment Of Localization In Cell Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Epidermis Development Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Tissue Development Positive Regulation Of Canonical Wnt Signaling Pathway Maintenance Of Protein Location In Cell Epithelium Development Microtubule-based Transport Maintenance Of Protein Location Maintenance Of Location In Cell Anatomical Structure Development Cytoskeleton-dependent Intracellular Transport Viral Process Developmental Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Macromolecule Catabolic Process Microtubule Anchoring Positive Regulation Of Wnt Signaling Pathway Keratinocyte Activation Positive Regulation Of Schwann Cell Proliferation Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Opsin Transport Mitotic Cell Cycle Checkpoint Regulation Of Organelle Organization Regulation Of Cell Cycle Axon Cargo Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Differentiation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Tagcloud ?			bisulfite chip deazaneplanocin determining dznep epigenetic h3k27me3 hsc3 hsc4 hypermethylated immunofluorescence insights keratin lys mechanistic modifications oscc osccs pathologies polycomb prc2 reactivated reportedly repressed repressive sas silenced transcriptionally trimethylation
Tagcloud (Difference) ?			bisulfite chip deazaneplanocin determining dznep epigenetic h3k27me3 hsc3 hsc4 hypermethylated immunofluorescence insights keratin lys mechanistic modifications oscc osccs pathologies polycomb prc2 reactivated reportedly repressed repressive sas silenced transcriptionally trimethylation
Tagcloud (Intersection) ?