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MAP2K5 and PARD6A
Number of citations of the paper that reports this interaction (PMID
12813044
)
67
Data Source:
HPRD
(two hybrid, in vivo)
MAP2K5
PARD6A
Gene Name
mitogen-activated protein kinase kinase 5
par-6 family cell polarity regulator alpha
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Spindle
Cytosol
Ruffle
Nucleus
Cytosol
Plasma Membrane
Tight Junction
Cell Cortex
Protein Complex
Apical Part Of Cell
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Rho GTPase Binding
GTP-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Signal Transduction
Heart Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Growth
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Response To Cytokine Stimulus
ERK5 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell Junction Assembly
Cell-cell Junction Organization
Cell-cell Junction Maintenance
Cell Division
Tight Junction Assembly
Pathways
Signalling to ERK5
Signalling by NGF
NGF signalling via TRKA from the plasma membrane
Loss of Function of TGFBR2 in Cancer
Cell junction organization
TGFBR2 MSI Frameshift Mutants in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Tight junction interactions
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Cell-cell junction organization
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Body mass index (
22344219
20935630
)
Obesity (
23563607
)
Restless legs syndrome (
17637780
21779176
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
15 interactors:
ASRGL1
BAD
CDC42BPB
ESRRA
MAP3K2
MAP3K3
MAPK7
PARD6A
PRKCI
PRKCZ
RPL28
SQSTM1
STAMBP
XRCC6
YWHAZ
24 interactors:
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
RAC1
RHOQ
TCP10
TGFBR1
WDR83
YWHAH
YWHAZ
Entrez ID
5607
50855
HPRD ID
03951
06316
Ensembl ID
ENSG00000137764
ENSG00000102981
Uniprot IDs
A6NK28
Q13163
Q9NPB6
PDB IDs
2NPT
2O2V
4IC7
1WMH
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Death
Response To Growth Factor
Signal Transduction
Cellular Response To Stimulus
Phosphorylation
Protein Phosphorylation
Signaling
Neurotrophin TRK Receptor Signaling Pathway
Cell Communication
Neurotrophin Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Apoptotic Process
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Signal Transduction
Response To Stimulus
Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Cellular Response To Organic Substance
Regulation Of Protein Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Membrane Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Membrane Potential
Positive Regulation Of Kinase Activity
Intracellular Transport
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Signaling
Regulation Of Endothelial Cell Apoptotic Process
Response To Transforming Growth Factor Beta
Positive Regulation Of Autophagy
Positive Regulation Of Glucose Import
Cellular Protein Modification Process
Regulation Of Cellular Localization
Positive Regulation Of Glucose Transport
Viral Process
Positive Regulation Of Transferase Activity
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell-cell Junction Organization
Nervous System Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Communication
Tight Junction Assembly
Signal Transduction
Regulation Of Cell Death
Regulation Of Cellular Component Organization
System Development
Positive Regulation Of Signal Transduction
Apical Junction Assembly
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transport
Establishment Or Maintenance Of Cell Polarity
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Transferase Activity
Cell Junction Assembly
Multicellular Organismal Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Generation Of Neurons
Wound Healing
Anatomical Structure Development
Cellular Response To Stimulus
Positive Regulation Of Cell Death
Cell-cell Junction Assembly
Neurogenesis
Regulation Of Establishment Of Protein Localization
Regulation Of Phosphorylation
Response To Wounding
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Protein Phosphorylation
Developmental Process
Regulation Of Protein Localization
Regulation Of Kinase Activity
Cellular Component Assembly
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
Tagcloud
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Difference)
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Intersection)
?