MAP2K5 and TERT

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K5	TERT
Description		mitogen-activated protein kinase kinase 5	telomerase reverse transcriptase
Image
GO Annotations	Cellular Component	Spindle	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Positive Regulation Of Cell Growth Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Telomere Maintenance Via Recombination Telomere Maintenance RNA-templated Transcription RNA-templated DNA Biosynthetic Process Protein Import Into Nucleus Telomere Maintenance Via Telomerase Mitochondrion Organization Heart Development DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway SiRNA Processing Regulation Of Protein Stability Positive Regulation Of Hair Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of D-glucose Import Response To Cadmium Ion Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence SiRNA Transcription Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of Transdifferentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signalling to ERK5	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs		Fostamatinib Pimasertib	Zidovudine Grn163l Tertomotide
Diseases			Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 22344219 24861553 28892062 28552196 28448500 25673413 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 33239738 17637780 21779176 29029846) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 19151717 24403052 25855136 31174203 33549134) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 20972438 24163127) Breast cancer ( 22037553 23535729 23535733 27117709 28171663 29059683) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 26956414 28165464) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 19578367 21531791 21827660 22886559 28346443 29743610 30714141) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 18835860 31710517) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 19836008 20700438 20871597 22797724 27393504 28604730) Lung cancer ( 18978790 21725308 23143601 27393504 31577861) Lung cancer in never smokers ( 28604730 31009812) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 28017375 29403010 32888494) Mean corpuscular volume ( 27863252 28017375 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 26545403 27436580) Neutrophil count ( 27863252 29403010 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 25086665 27579533 29422604) Platelet count ( 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 21743467 25939597 31562322) Prostate-specific antigen levels ( 28139693 30410027) Red blood cell count ( 20139978 27863252 29403010 32888494) Serum prostate-specific antigen levels ( 21160077) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 27863252 29403010 32888494)
Interacting Genes		56 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 UBC XRCC6 YWHAZ ZNF426 ZNF620	81 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 PTPA RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP USP7 XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		5607	7015
HPRD ID		03951	01754
Ensembl ID		ENSG00000137764	ENSG00000164362
Uniprot IDs		Q13163	O14746
PDB IDs		2NPT 2O2V 4IC7	2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW 7BG9 7QXA 7QXB 7QXS 7TRD 7TRE 7TRF 7V99
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Signal Transduction Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Cell Population Proliferation MAPK Cascade Animal Organ Development Cellular Response To Stress Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cell Differentiation ATP Binding Negative Regulation Of Signal Transduction Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen Levels Regulation Of MAPK Cascade Phosphorylation Cellular Developmental Process Regulation Of Cell Cycle Positive Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Nucleus Regulation Of Protein Localization To Nucleus Cytoplasm Regulation Of Apoptotic Signaling Pathway Developmental Process Regulation Of Developmental Process Response To Decreased Oxygen Levels Transferase Activity Nucleotide Binding	Regulation Of Primary Metabolic Process Cellular Response To Stress Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Activity ATP Binding Regulation Of Chromosome Organization Telomere Maintenance Kinase Activity Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Regulation Of Organelle Organization Organelle Organization Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Nucleotide Binding Telomere Organization Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Telomere Maintenance Via Telomere Lengthening Intracellular Signaling Cassette Cytoplasm Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of DNA Biosynthetic Process Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of Signal Transduction
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