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MAP2K5
Gene Name
mitogen-activated protein kinase kinase 5
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Spindle
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Signal Transduction
Heart Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Growth
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Response To Cytokine Stimulus
ERK5 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signalling to ERK5
Signalling by NGF
NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Body mass index (
22344219
20935630
)
Obesity (
23563607
)
Restless legs syndrome (
17637780
21779176
)
Protein-protein Interactions
15 interactors:
ASRGL1
BAD
CDC42BPB
ESRRA
MAP3K2
MAP3K3
MAPK7
PARD6A
PRKCI
PRKCZ
RPL28
SQSTM1
STAMBP
XRCC6
YWHAZ
Entrez ID
5607
HPRD ID
03951
Ensembl ID
ENSG00000137764
Uniprot IDs
A6NK28
Q13163
PDB IDs
2NPT
2O2V
4IC7
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Death
Response To Growth Factor
Signal Transduction
Cellular Response To Stimulus
Phosphorylation
Protein Phosphorylation
Signaling
Neurotrophin TRK Receptor Signaling Pathway
Cell Communication
Neurotrophin Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Apoptotic Process
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Signal Transduction
Response To Stimulus
Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Cellular Response To Organic Substance
Regulation Of Protein Localization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction
Membrane Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Membrane Potential
Positive Regulation Of Kinase Activity
Intracellular Transport
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Signaling
Regulation Of Endothelial Cell Apoptotic Process
Response To Transforming Growth Factor Beta
Positive Regulation Of Autophagy
Positive Regulation Of Glucose Import
Cellular Protein Modification Process
Regulation Of Cellular Localization
Positive Regulation Of Glucose Transport
Viral Process
Positive Regulation Of Transferase Activity
Tagcloud
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
maximise
mek5
men1
nbpf10
ncor2
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded